Results 51 to 60 of about 58,536 (309)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Effects of Encapsulation and In Vitro Digestion on Anthocyanin Composition and Antioxidant Activity of Raspberry Juice Powder

Foods
Microbeads of raspberry extract were produced using encapsulation matrices alginate + pea protein isolate + psyllium mucilage, alginate + pea protein isolate + psyllium mucilage + okra, and alginate + pea protein isolate + psyllium mucilage + Aloe ferox ...
Mokgaetji Johanna Mokale, Sreejarani Kesavan Pillai, Dharini Sivakumar   +2 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Inhancing nutritive value of local grass pea seed (Lathyrus sativus L.) used as a partial replacement of soybean meal in broiler diet [PDF]

Iraqi Journal of Veterinary Sciences, 2009
This study was carried out at the poultry farm of the College of Agriculture, University of Tikrit aiming to inhancing the nutritional value of local grass pea used as replacement of soybean meal using enzymes or and probiotic in broiler diet, 810 day ...
A. K. Ahmed* and M A. Al-Neaemi**
doaj   +1 more source

Impact of vitamin D3 Nanoemulsion on spermatogenesis and antioxidant enzymes in Vitamin D deficient induced albino male rats.

Zanco Journal of Pure and Applied Sciences, 2021
Vitamin D deficiency is common with several effects that include nonskeletal impacts. Many studies showed associations between Vitamin D deficiency and oxidative statues with disturbed testicles in male rats (Rattus norvegicus) which might be improved ...
Diyar Hamid Karim, Sulaf Mustafa Mohammed, Hoshyar Abdullah Azeez   +2 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Effect of pH-shifting on the Physicochemical Properties of Pea Proteins and Its Effect on the Texture of Hybrid Gels Formed with Casein Micelles

Foods
Hybrid systems combining animal and plant proteins are promising for developing sustainable, high-protein foods. However, structural incompatibility between proteins like casein and pea protein hinders the formation of stable systems such as gels.
Raiane Rodrigues da Silva, Luis Henrique de Paula Souza, Lucas Silva de Sousa, Laura Destro Rodrigues, Gustavo Schäfer Nogueira, Luis Gustavo Lima Nascimento, Antônio Fernandes Carvalho   +6 more
doaj   +1 more source

Development of optimal method of obtaining pea isolated proteins for use in breeding for quality

Аграрная наука Евро-Северо-Востока, 2020
The article provides the results of the experiments on determination of optimal parameters for obtaining isolated proteins from grains of cultivated and wild pea for use in breeding for quality.
S. V. Bobkov, O. V. Uvarova
doaj   +1 more source

Protein Content and Anti-nutritional Factors in Pigeon Pea and Effect of Its Protein Isolate on Physical Properties and Consumer Preference of Beef Sausages

Applied Food Research, 2022
Prolonged consumption of chemical binders in sausage can cause health effects. Pigeon pea is rich in protein which can be isolated and used as an alternative to chemicals and soybean protein in the manufacture of sausages. The objective of this study was
Alice D. Gomezulu, Richard J. Mongi
doaj   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source