Results 61 to 70 of about 5,856 (180)

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Peach Buds’ Microbiome Profiling Reveals Cultivar-Specific Signatures Associated with TCSB Susceptibility

Stresses
The plant microbiome plays a pivotal role in host development and resilience against biotic and abiotic stresses. In perennial crops like peach, microbial communities inhabiting dormant buds—critical yet vulnerable organs—may influence disease outcomes ...
Antonella Cardacino, Taner Tastekin, Federico Brugneti, Marco Cirilli, Angelo Mazzaglia, Silvia Turco   +5 more
doaj   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Insights into the Interaction between the Biocontrol Agent Bacillus amyloliquefaciens QST 713, the Pathogen Monilinia fructicola and Peach Fruit

Agronomy
Brown rot disease caused by Monilinia fructicola is one of the most important peach fruit threats in the world. The use of biological control agents (BCAs), instead of synthetic fungicides, to successfully inhibit postharvest disease development is a ...
Polina C. Tsalgatidou, Anastasia Papageorgiou, Anastasia Boutsika, Michael Chatzidimopoulos, Costas Delis, Dimitrios I. Tsitsigiannis, Epaminondas Paplomatas, Antonios Zambounis   +7 more
doaj   +1 more source

Research on chemical control of peach shoot blight and the association between phloem volatile compounds and resistance [PDF]

Guoshu xuebao
[Objective] Prunus persica (L.) Batsch, a member of the Rosaceae family, is native to China and has a cultivation and evolutionary history spanning thousands of years.
HU Zhu, WANG Li, ZHAO Hongyue
doaj   +1 more source

Anastrepha grandis: Distribution, Host Plants, and Management—A Review

Entomologia Experimentalis et Applicata, EarlyView.
This graphic summary illustrates the databases and languages used in the bibliographic search for the review of the geographic distribution of Anastrepha grandis (Diptera: Tephritidae) in the Americas and different regions of Brazil, the main host plants of the Cucurbitaceae family, the management strategies used, and the main challenges related to the
Liz Maria Matilde Duarte, Manoel Araécio Uchoa, Isaias de Oliveira   +2 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Identification, Biology, and Bactericide Control of Peach Bacterial Shot Hole in Hebei Province, China

Microorganisms
Peach bacterial shot hole is a major disease limiting the yield and quality in most peach-producing areas worldwide. To clarify its etiology and support the development of targeted management strategies, diseased samples were collected from Changli ...
Jianchao Cui, Haijiao Xu, Liying Fan, Yu Wang, Limin He, Zhaoyuan Wang, Jicheng Han, Jie Li, Qihang Tian, Wenshi Zhao, Yonghong Li   +10 more
doaj   +1 more source

Epidemiology of Children and Young People Presenting to Australian Emergency Departments for the Management of Acute Severe Behavioural Disturbance: Secondary Analysis of a Randomised Controlled Trial

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To describe the epidemiological characteristics of children and young people presenting to the emergency department (ED) with acute severe behavioural disturbance (ASBD) who were deemed to require oral sedative medication. Methods Secondary analysis of a randomised controlled open‐label multi‐centre trial of oral olanzapine versus oral ...
Elyssia M. Bourke, Kate Klein, Chris J. Selman, Katherine J. Lee, Amit Kochar, Deborah Shellshear, Meredith L. Borland, Shane George, Shefali Jani, Doris Tham, Michael Gordon, Chidambaram Prakash, Andrew Davidson, Catherine L. Wilson, Natalie Phillips, Gaby Nieva, Jonathan C. Knott, Franz E. Babl, Simon S. Craig, on behalf of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Hanan ElGharib, Lauren Page, Vivian Truong, Naomi Loftus, Danielle Kallianiotis, Amy Carle, Amanda Williams, Bojana Gladanac, Sharon O'Brien, Patricia Clifford, Melissa O'Brien Smith, Anne‐Maree O'Regan, Lisa Properjohn, Katy Whitten, Catherine Power, Gaby Nieva, Simone Hughes, Lara Caruso, Katie Northcott, Natalie Phillips, Angus Jones, Anne Hinde, Amy Coulson, Nadia Schmidt, Jessica Waghorn, Marietta John‐White, Riku Haataja, Zachary Wilder, Deepali Thosar, Areeba Athar   +49 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source