Results 81 to 90 of about 13,924,728 (234)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

A real time monitoring system for accurate plant leaves disease detection using deep learning

Crop Design
Accurate and timely detection of plant diseases is crucial for sustainable agriculture and food security. This research presents a real-time monitoring system utilizing deep learning techniques to detect diseases in plant leaves with high accuracy.
Kazi Naimur Rahman, Sajal Chandra Banik, Raihan Islam, Arafath Al Fahim   +3 more
doaj   +1 more source

Epidemiology of Children and Young People Presenting to Australian Emergency Departments for the Management of Acute Severe Behavioural Disturbance: Secondary Analysis of a Randomised Controlled Trial

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To describe the epidemiological characteristics of children and young people presenting to the emergency department (ED) with acute severe behavioural disturbance (ASBD) who were deemed to require oral sedative medication. Methods Secondary analysis of a randomised controlled open‐label multi‐centre trial of oral olanzapine versus oral ...
Elyssia M. Bourke, Kate Klein, Chris J. Selman, Katherine J. Lee, Amit Kochar, Deborah Shellshear, Meredith L. Borland, Shane George, Shefali Jani, Doris Tham, Michael Gordon, Chidambaram Prakash, Andrew Davidson, Catherine L. Wilson, Natalie Phillips, Gaby Nieva, Jonathan C. Knott, Franz E. Babl, Simon S. Craig, on behalf of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Hanan ElGharib, Lauren Page, Vivian Truong, Naomi Loftus, Danielle Kallianiotis, Amy Carle, Amanda Williams, Bojana Gladanac, Sharon O'Brien, Patricia Clifford, Melissa O'Brien Smith, Anne‐Maree O'Regan, Lisa Properjohn, Katy Whitten, Catherine Power, Gaby Nieva, Simone Hughes, Lara Caruso, Katie Northcott, Natalie Phillips, Angus Jones, Anne Hinde, Amy Coulson, Nadia Schmidt, Jessica Waghorn, Marietta John‐White, Riku Haataja, Zachary Wilder, Deepali Thosar, Areeba Athar   +49 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Tripartite Interaction Between Penicillium pinophilum‐Host Plants and CMV‐Y: A Model for Endophyte‐Mediated Viral Biocontrol

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant‐fungus‐virus tripartite interactions represent complex ecological systems in which mutualistic endophytes can influence host physiology, yet the molecular basis of endophyte‐mediated defence remains poorly understood. Here, we demonstrate that the endophytic fungus Penicillium pinophilum EU0013 suppresses the yellow strain of cucumber ...
Sarah R. Ibiang, Ivan Galis, Hideki Kondo, Nobuhiro Suzuki   +3 more
wiley   +1 more source

Marketing Portfolio Choices by Independent Peach Growers: An Application of the Polychotomous Selection Model [PDF]

In selecting a marketing channel for fresh peach sales, Georgia commercial peach growers choose the channel after accounting for buyers' preferences for quality attributes.
Bilgic, Abdulbaki, Florkowski, Wojciech J., Park, Timothy A.   +2 more
core  

The effects of bed rest on cardiometabolic health: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract Horizontal bed rest (HBR) and head‐down tilt (HDT) are models of physical inactivity. In this systematic review and meta‐analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR and HDT in healthy adults. Following the PRISMA guidelines, we searched PubMed, Scopus, Web of Science and Cochrane Library until 1 October 2025 ...
Konstantinos Prokopidis, Tyler Daubrah‐Scott, Alyssa Varanoske, Jordi Morwani‐Mangnani, David D. Church, Colleen S. Deane, Bethan E. Phillips, Emily J. Arentson‐Lantz   +7 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Fungal Pathogens of Peach Palm Leaf Spot in Thailand and Their Fungicide Sensitivity

Journal of Fungi
Peach palm (Bactris gasipaes Kunth) is a long-lived tropical palm valued for its edible, nutritious fruits. The cultivation area of peach palm, which was introduced to Thailand for fruit production, has been steadily expanding.
Prisana Wonglom, Nakarin Suwannarach, Jaturong Kumla, Anurag Sunpapao   +3 more
doaj   +1 more source