Results 21 to 30 of about 6,153 (148)

Role of the mTOR pathway in normal and tumoral adrenal cells [PDF]

, 2010
The mammalian target of rapamycin (mTOR) is a kinase of the phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT) signaling pathway, which is one of the most important intracellular mediators of the activity of growth factors receptors ...
Hofland, L.J. (Leo), Koetsveld, P.M. (Peter) van, Martino, M.C. (Maria Cristina) de, Pivonello, R. (Rosario)   +3 more
core   +1 more source

Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors [PDF]

, 2015
Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present
Allolio, Allolio, Allolio, Almeida, Arap, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baudin, Casal, Chuang, Dewhirst, Fassnacht, Formby, Gillies, Gottlieb, Group, Halestrap, Halestrap, Halestrap, Hammer, Krause, Kroiss, Lacroix, Latronico, Maini, Mendonca, Mueller-Klieser, Papotti, Pouyssegur, Pouyssegur, Prasad, Sandrini, Sen, Tabarin, Toole, Weiss   +41 more
core   +3 more sources

Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study [PDF]

, 2017
Background: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (
Christine Spitzweg, Christoph-Thomas Germer, Felix Megerle, Johannes Baur, Marcus Quinkler, Martin Fassnacht, Matthias Kroiss, on behalf of the German Adrenocortical Carcinoma Study Group, Peter Nawroth, Timo Deutschbein, Tjark-Ole Büntemeyer, Ulrich Steger   +11 more
core   +1 more source

Ultrasonography of the Adrenal Gland [PDF]

, 2007
With appropriate techniques and using liver, spleen or kidney as an acoustic window, normal adrenal gland and adrenal lesions can be delineated by ultrasonography. The right adrenal gland is usually evaluated by transverse oblique scans and coronal scans,
Brandsma, Rick, de Koning, Tom J., Eggink, Hendriekje, Lange, Fiete, Tijssen, Marina A. J., van der Hoeven, Johannes H.   +5 more
core   +1 more source

ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland [PDF]

, 2010
The nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) is a key regulator of adrenal and gonadal biology. Disruption of SF-1 can lead to disorders of adrenal development, while increased SF-1 dosage has been associated with adrenocortical ...
Bruno Ferraz‐de‐Souza, Ishimoto H., Ishimoto H., John C. Achermann, Lin Lin, Mehul T. Dattani, Mike Hubank, Nipurna Jina, Sonia Shah, Souza B., Souza B., Zhao Y.   +11 more
core   +2 more sources

O espectro das síndromes de hipertensão esteróide na infância e adolescência [PDF]

, 2001
Arterial hypertension is not a privilege of adults. Besides renal and vascular causes, adrenocortical and correlated diseases must be considered when investigating a hypertensive child or adolescent.
Costa-Santos, Marivânia, Kater, Claudio Elias   +1 more
core   +3 more sources

Ectopic Low-grade Adrenocortical Carcinoma in the Spinal Region [PDF]

American Journal of Surgical Pathology, 2009
Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection.
Fausto J, Rodriguez, Bernd W, Scheithauer, Lori A, Erickson, Robert B, Jenkins, Caterina, Giannini   +4 more
openaire   +2 more sources

Germline TP53 mutational spectrum in French Canadians with breast cancer [PDF]

, 2012
Background Specific germline mutations in the hereditary breast-ovarian cancer susceptibility (HBC/HBOC) genes, BRCA1, BRCA2 and PALB2, have been shown to recur in French Canadians of Quebec, Canada, and this has been attributed to common
Suzanna L Arcand, Mohammed R Akbari, Anne-Marie Mes-Masson, Diane Provencher, William D Foulkes, Steven A Narod, Patricia N Tonin   +6 more
core   +1 more source

Genotype–Phenotype Correlations of Li–Fraumeni Syndrome in Japan Children's Cancer Group LFS20 Study Cohort

Cancer Science, EarlyView.
This study investigates genotype–phenotype correlations in Japanese families with germline TP53 pathogenic variants, collected through a nationwide prospective cancer surveillance study (JCCG LFS‐20). Among 41 families analyzed, 36 met criteria for Li–Fraumeni syndrome (LFS), and 5 were classified as attenuated LFS.
Fumito Yamazaki, Yoshiko Nakano, Masashi Sanada, Hiroki Kurahashi, Shunsuke Miyai, Arisa Ueki, Yuko Watanabe, Daisuke Hasegawa, Shuhei Karakawa, Toshifumi Ozaki, Akira Hirasawa, Akiko M. Saito, Eisuke Inoue, Motohiro Kato, Hiroyoshi Hattori   +14 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source