Results 31 to 40 of about 6,153 (148)

MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen [PDF]

, 2016
Additional file 2: Figure S2. Representative flow cytometric histograms of CRC cell lines 72 h post transfection with pre-miR-210 and a control miRNA, respectively.
Anne Fassl, Jutta Richter, Katrin E. Tagscherer, Sabrina Schecher, Stephan Macher-Goeppinger, Tabea Sinkovic, Wilfried Roth   +6 more
core   +4 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Texture image analysis in differentiating malignant from benign adrenal cortical tumors in children and adults [PDF]

, 2009
OBJECTIVE: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT).
Castelo, A., Longatto Filho, Adhemar, Mendonça, B., Montironi, R., Santanelli, A., Shirata, Neuza Kasumi, Sredni, S. T., Zerbini, M. C. N.   +7 more
core   +1 more source

Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent [PDF]

, 2014
Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types.
Bouche, Gauthier, Meheus, Lydie, Pantziarka, Pan, Sukhatme, Vidula, Sukhatme, Vikas P   +4 more
core   +1 more source

Pediatric Mixed Functioning Adrenocortical Carcinoma: A Case Report and Review of Literature

Middle East Journal of Cancer, 2019
Adrenocortical carcinoma (ACC) is a very rare disease in the pediatric age group. The clinic-biological profile, histopathological criteria of diagnosis, and staging of this disease in this age group are different from those of adult ACC. In this paper, we report a case of pediatric ACC presenting as Cushing syndrome that was managed with complete ...
Yadav, Sanjay, Jha, Chandan, Mishra, Saroj, Verma, Ritu, Krishna, Abhishek   +4 more
openaire   +2 more sources

Establishment and Characterization of the First Pediatric Adrenocortical Carcinoma Xenograft Model Identifies Topotecan as a Potential Chemotherapeutic Agent [PDF]

Clinical Cancer Research, 2013
Abstract Purpose: Pediatric adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Conventional chemotherapeutic agents have shown limited utility and are largely ineffective in treating children with advanced ACC.
Emilia M, Pinto, Christopher, Morton, Carlos, Rodriguez-Galindo, Lisa, McGregor, Andrew M, Davidoff, Kimberly, Mercer, Larisa V, Debelenko, Catherine, Billups, Raul C, Ribeiro, Gerard P, Zambetti   +9 more
openaire   +2 more sources

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

Targeting pediatric adrenocortical carcinoma: Molecular insights and emerging therapeutic strategies

Cancer Treatment Reviews
Pediatric adrenocortical carcinoma (pACC) is an exceptionally rare and aggressive malignancy, accounting for only 0.2-0.3% of childhood cancers. Characterized by significant endocrine activity and often associated with genetic syndromes such as Li-Fraumeni syndrome, pACC exhibits distinct clinical and molecular profiles compared to adult adrenocortical
Michaela Kuhlen, Maximilian Schmutz, Marina Kunstreich, Antje Redlich, Rainer Claus   +4 more
openaire   +2 more sources

Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma

Oncology Letters, 2017
Pediatric adrenocortical carcinoma and adrenocortical adenoma are two rare diseases affecting children. Molecular analyses were performed to identify commonalities in gene expression between the diseases. Differentially expressed genes were identified for the pediatric adrenocortical adenoma and carcinoma tissues, as compared with normal tissues, using
Anurag, Kulshrestha, Shikha, Suman
openaire   +3 more sources

Clinical Features and Treatment Strategies of Li‐Fraumeni Syndrome Patients With Inherited TP53 Mutations

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
LFS with TP53 disease‐causing mutations may be potential beneficiaries of immune checkpoint inhibitors and targeted therapies. Therefore, NGS and PD‐L1 testing should be performed in all LFS patients. ABSTRACT Background Li‐Fraumeni syndrome is a rare autosomal dominant disorder caused by a pathogenic mutation of the tumor suppressor gene TP53.
Keyu Chen, Yufen Xu, Binbin Song, Yuyang Gu, Xiaofang Xu, Jun Cao, Meiyu Fang   +6 more
wiley   +1 more source