Results 51 to 60 of about 6,153 (148)

Hepatoblastoma and microRNA-483 two forms and one outcome [PDF]

, 2016
Hepatoblastoma (HB) is the most common liver cancer in infants younger than 3 years. Its onset has been associated with other genetic syndromes and some genetic and biochemical markers has been identified recently in this neoplasia.
Basso, E., Brunati, A., David, E., Flamini, Valentina, Magrelli, A., Romagnoli, R., Salvatore, M., Taruscio, D.   +7 more
core   +1 more source

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss

MedComm, Volume 6, Issue 9, September 2025.
In this study, we found the close proximity of NUDT15 and RB1 in terms of chromosome location and exploited the fact that NUDT15 deficiency induces 6MP‐related adverse drug reactions, thus providing a possible collateral lethality (a specific type of synthetic lethality) strategy to treat RB1‐deficient tumors (created with www.biorender.com).
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
wiley   +1 more source

The PI3K/Akt Pathway in Tumors of Endocrine Tissues [PDF]

, 2016
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its ...
Hague, Angela, Robbins, Helen Louise
core   +2 more sources

A patient with newly diagnosed breast cancer found to have mosaic TP53 likely pathogenic variant

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Hetal D. Mistry, MacKenzie R. Adams, Charu Taneja, Lauren J. Massingham, Elizabeth H. Dibble, Kara L. Leonard, Jesse Hart, Galina G. Lagos, Mary Anne Fenton   +8 more
wiley   +1 more source

The Impact of a Personal Cancer Diagnosis on the Psychological Health of Adolescent/Young Adult Cancer Survivors: A Mixed Methods Study

Psycho-Oncology, Volume 34, Issue 9, September 2025.
ABSTRACT Background Adolescent/young adult cancer survivors (AYACS), describing people diagnosed with cancer between 15 and 39 years old across the cancer continuum, suffer from poor psychological health. Poor psychological health is associated with difficulty achieving professional goals, financial stress, and poorer health. Aims The objective of this
Pooja Rao, Katie A. Devine, Kristin Bingen, Allison M. Scott, Laura M. Koehly, Courtney L. Rumbaugh, Emily Wasserman, Heather J. Costigan, Smita Dandekar, Natthapol Songdej, George F. Blackall, Eugene J. Lengerich, Lauren J. Van Scoy   +12 more
wiley   +1 more source

EVALUATION OF CURRENT CLINICAL CRITERIA FOR LI-FRAUMENI SYNDROME IN A DIVERSE SAMPLE OF TP53 MUTATION CARRIERS [PDF]

, 2014
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by heterozyogous germline mutations in the TP53 gene and characterized by an excess of early-onset cancers, high lifetime risk of cancer, and a wide range of tumor types ...
Parham, Emily A
core  

Clinicopathological Features of Pediatric Functional Adrenocortical Carcinoma Diagnosed by Weiss Criteria; An Analysis of Four Cases.

Clinical Pediatric Endocrinology, 2001
Histological differentiation between benign and malignant adrenocortical tumors is currently based on the criteria of Weiss et al. (Weiss criteria) and vimentin immunostaining, but the prognostic values of the criteria in pediatric cases are still unclear. We analyzed the histological features, immunostaining status of p53, vimentin, Ki67 and cyclin-A,
Yoko Misu, Shi-Xu Jiang, Yukifumi Yokota, Masahiko Shibata, Osamu Shinohara, Toru Kameya, Nobuo Matsuura   +6 more
openaire   +2 more sources

Changes in multi‐gene cancer panels for children: A 4‐year retrospective review

Journal of Genetic Counseling, Volume 34, Issue 4, August 2025.
Abstract The multi‐gene panel is the most utilized genetic test to evaluate for germline cancer predisposition syndromes. However, the rate of change of commercial multigene panels is not well understood, and its value as a standalone test has also not been investigated.
Elise G. Williams, Elena Kessler, Kristine L. Cooper, Andrea Durst, Julia Meade   +4 more
wiley   +1 more source

Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model [PDF]

, 2015
The available drug treatment options for adrenocortical carcinoma (ACC) are limited. In our previous studies, the in vitro activity of 9-cis retinoic acid (9-cisRA) on adrenocortical NCI-H295R cells was shown along with its antitumoral effects in a small
Baghy, Kornélia, Butz, Henriett, Hunyadi-Gulyás, Éva Csilla, Igaz, Péter, Kovalszky, Ilona, Medzihradszky F., Katalin, Micsik, Tamás, Nagy, Zoltán, Nyírő, Gábor, Patócs, Attila Balázs, Perge, Pál, Rácz, Gergely, Rácz, Károly   +12 more
core  

Pediatric Adrenocortical Carcinoma: Diagnostic Challenges and Therapeutic Approach — A Case Report

Iranian Journal of Pediatric Hematology & Oncology
Adrenocortical carcinoma (ACC) is a rare tumor. It constitutes 0.2% of malignant tumors in children and it is considered ten times rarer than in adults. Patients with predisposing syndromes like Li-Fraumeni or Beckwith-Wiedemann may develop these tumors. Clinical symptoms are dominated by endocrine signs, which are present in 90% of cases. The primary
Assia Haif, Djelloul Achouri
openaire   +1 more source