Results 61 to 70 of about 1,054,709 (177)

Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging

, 2021
Adrenocortical carcinoma (ACC) is a heterogenous group of diseases with different clinical behaviour between adult and paediatric patients. In addition, three histological variants, oncocytic, myxoid and sarcomatoid are noted on the recent World Health ...
Lam, Alfred King-yin, Alfred King-yin Lam   +1 more
core   +1 more source

Pan-cancer atlas of somatic core and linker histone mutations

npj Genomic Medicine, 2023
Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone gene mutations in malignant tumors ...
Erin R. Bonner, Adam Dawood, Heather Gordish-Dressman, Augustine Eze, Surajit Bhattacharya, Sridevi Yadavilli, Sabine Mueller, Sebastian M. Waszak, Javad Nazarian   +8 more
doaj   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, Volume 117, Issue 3, Page 642-652, September 2026.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Ectopic Low-grade Adrenocortical Carcinoma in the Spinal Region [PDF]

American Journal of Surgical Pathology, 2009
Ectopic adrenocortical neoplasms arising in the nervous system are very rare. We encountered an intradural, extramedullary case of an adrenocortical neoplasm of indeterminate malignant potential affecting a spinal nerve root in the distal lumbar region of a 5-month-old girl. The lesion recurred 6 months after the initial gross total resection.
Fausto J, Rodriguez, Bernd W, Scheithauer, Lori A, Erickson, Robert B, Jenkins, Caterina, Giannini   +4 more
openaire   +2 more sources

Evaluation of Claim Reports for Potential Impact of COVID-19 on Pediatric Dental Procedures [PDF]

, 2023
Purpose: To evaluate whether the postponement of dental elective procedures at the start of the COVID-19 pandemic was associated with an increased number of simple dental extractions, and/or decreased restorative procedures by analyzing data obtained ...
Vinson, LaQuia, Bauer, Brittany A., Sanders, Brian J., Eckert, George, Yepes, Juan F.   +4 more
core   +1 more source

Virilizing adrenocortical carcinoma in a female child of Li-Fraumeni syndrome

Indian Journal of Pathology and Microbiology
Adrenocortical carcinoma is a rare malignancy and even rarer in infancy. Most of these tumors in the pediatric age group are hormonally active and predominantly present with virilization.
K V Vishnu Sankar, Debansu Sarkar, Dilip Kumar Pal, Uttara Chatterjee   +3 more
doaj   +1 more source

Omics Biomarkers in Precision Oncology: From the Lens of the ASCPT Biomarkers and Translational Tools and Oncology Communities

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Omics biomarkers comprise several molecular entities, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic signatures. They play an essential role in oncology drug development and clinical settings by enabling personalized medicine.
Mai Mehanna, Hardik Mody, Joy C. Hsu, Julia Quintanilha, Zachary L. Taylor, Angela James, Binita Rajbanshi, Pooja Manchandani, Lakshmi Manasa Chekka   +8 more
wiley   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Mitotane-Induced Endocrine Alterations in Children with Adrenocortical Carcinoma: Clinical Implications from a 20-Year Retrospective Study

Children
Background/Objectives: Mitotane is a key component in the treatment of adrenocortical carcinoma (ACC), but its endocrine side effects in children remain under-characterized. Methods: We conducted a retrospective analysis of 11 pediatric patients (6 males,
Gerdi Tuli, Jessica Munarin, Stefano Gabriele Vallero, Matilde Piglione, Eleonora Biasin, Luisa De Sanctis, Franca Fagioli   +6 more
doaj   +1 more source