Results 71 to 80 of about 19,884 (196)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Texture image analysis in differentiating malignant from benign adrenal cortical tumors in children and adults [PDF]

, 2009
OBJECTIVE: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT).
Castelo, A., Longatto Filho, Adhemar, Mendonça, B., Montironi, R., Santanelli, A., Shirata, Neuza Kasumi, Sredni, S. T., Zerbini, M. C. N.   +7 more
core   +1 more source

Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors [PDF]

, 2015
Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present
Allolio, Allolio, Allolio, Almeida, Arap, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baudin, Casal, Chuang, Dewhirst, Fassnacht, Formby, Gillies, Gottlieb, Group, Halestrap, Halestrap, Halestrap, Hammer, Krause, Kroiss, Lacroix, Latronico, Maini, Mendonca, Mueller-Klieser, Papotti, Pouyssegur, Pouyssegur, Prasad, Sandrini, Sen, Tabarin, Toole, Weiss   +41 more
core   +3 more sources

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Pan-cancer atlas of somatic core and linker histone mutations

npj Genomic Medicine, 2023
Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone gene mutations in malignant tumors ...
Erin R. Bonner, Adam Dawood, Heather Gordish-Dressman, Augustine Eze, Surajit Bhattacharya, Sridevi Yadavilli, Sabine Mueller, Sebastian M. Waszak, Javad Nazarian   +8 more
doaj   +1 more source

The PI3K/Akt Pathway in Tumors of Endocrine Tissues [PDF]

, 2016
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden’s disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its ...
Hague, Angela, Robbins, Helen Louise
core   +2 more sources

Genotype–Phenotype Correlations of Li–Fraumeni Syndrome in Japan Children's Cancer Group LFS20 Study Cohort

Cancer Science, Volume 117, Issue 3, Page 836-840, March 2026.
This study investigates genotype–phenotype correlations in Japanese families with germline TP53 pathogenic variants, collected through a nationwide prospective cancer surveillance study (JCCG LFS‐20). Among 41 families analyzed, 36 met criteria for Li–Fraumeni syndrome (LFS), and 5 were classified as attenuated LFS.
Fumito Yamazaki, Yoshiko Nakano, Masashi Sanada, Hiroki Kurahashi, Shunsuke Miyai, Arisa Ueki, Yuko Watanabe, Daisuke Hasegawa, Shuhei Karakawa, Toshifumi Ozaki, Akira Hirasawa, Akiko M. Saito, Eisuke Inoue, Motohiro Kato, Hiroyoshi Hattori   +14 more
wiley   +1 more source

Ultrasonography of the Adrenal Gland [PDF]

, 2007
With appropriate techniques and using liver, spleen or kidney as an acoustic window, normal adrenal gland and adrenal lesions can be delineated by ultrasonography. The right adrenal gland is usually evaluated by transverse oblique scans and coronal scans,
Brandsma, Rick, de Koning, Tom J., Eggink, Hendriekje, Lange, Fiete, Tijssen, Marina A. J., van der Hoeven, Johannes H.   +5 more
core   +1 more source

Ethical considerations of genetic and genomic testing in pediatric oncology: A narrative review

CA: A Cancer Journal for Clinicians, Volume 76, Issue 2, March/April 2026.
Abstract Genomics—and genomic testing in particular—has transformed oncology, facilitating both targeted therapies and personalized care. In pediatric oncology, unique clinical and ethical considerations arise. Compared with adults, children and adolescents are affected by more limited evidence regarding test performance, variant interpretation, and ...
Brittany L. Greene, Jonathan M. Marron
wiley   +1 more source

Common module analysis reveals prospective targets and mechanisms of pediatric adrenocortical adenoma and carcinoma

Oncology Letters, 2017
Pediatric adrenocortical carcinoma and adrenocortical adenoma are two rare diseases affecting children. Molecular analyses were performed to identify commonalities in gene expression between the diseases. Differentially expressed genes were identified for the pediatric adrenocortical adenoma and carcinoma tissues, as compared with normal tissues, using
Anurag, Kulshrestha, Shikha, Suman
openaire   +3 more sources