Results 121 to 130 of about 1,413,284 (292)

Sotatercept administration in a young infant with severe pulmonary arterial hypertension: A case report

Frontiers in Pediatrics
Idiopathic pulmonary arterial hypertension (PAH) in infants is a rare, life-threatening condition characterized by elevated pulmonary artery pressure resulting from endothelial dysfunction, vasoconstriction, and vascular remodeling. The treatment options
Arjith V. Rathakrishnan, Jenna Torgeson, Arij Beshish, Arij Beshish, Monica C. Bogenschutz, Monica C. Bogenschutz, Vivek Balasubramaniam, Vivek Balasubramaniam, Luke J. Lamers, Luke J. Lamers   +9 more
doaj   +1 more source

Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency. [PDF]

, 2015
In patients with idiopathic pulmonary arterial hypertension (iPAH), iron deficiency is common and has been associated with reduced exercise capacity and worse survival. Previous studies have shown beneficial effects of intravenous iron administration. In
Ruiter, G, van der Laarse, W.J., Howard, LS, Vonk‐Noordegraaf Anton, Chris M. Happé, Happe, C.M., Luke S. Howard, Westerhof, N, Schalij, I, Howard, L.S., Wilkins, MR, Emmy Manders, Ruiter, G., van der Laarse, WJ, Westerhof, N., Schalij, I., Manders, E, Happé, CM, Harm J. Bogaard, Bogaard, HJ, de Man, FS, Wilkins, M.R., Groepenhoff, H, Bogaard, H.J., de Man, F.S., Gerrina Ruiter, Herman Groepenhoff, Frances S. de Man, Vonk-Noordegraaf, A, Vonk-Noordegraaf, A., Willem J. van der Laarse, Ingrid Schalij, Manders, E., Groepenhoff, H., Nico Westerhof, Martin R. Wilkins   +35 more
core   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

76. Profile and spectrum of congenital heart defect in pediatric patient with down syndrome

Journal of the Saudi Heart Association, 2016
Down syndrome is one of the most common chromosomal abnormality worldwide. It occurs in 1 of every 800 live births. Almost one-half of patients with Down Syndrome have congenital heart defect.
G. Alsuhaibani, N. Alotaibi, R. Alanazi, S. Alshihri, A. Alhuzaimi   +4 more
doaj   +1 more source

Chronic thromboembolic pulmonary hypertension from the perspective of patients with pulmonary embolism [PDF]

, 2018
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but feared long-term complication of acute pulmonary embolism (PE), although CTEPH may occur in patients with no history of symptomatic venous thromboembolism.
M. Delcroix, Klok, F A, Bogaard, H.J., Delcroix, M., Bogaard, H J, Delcroix, M, Klok, F.A., F.A. Klok, H.J. Bogaard   +8 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Right Ventricular Fibrosis: A Pathophysiological Factor in Pulmonary Hypertension?

, 2019
The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV.
Andersen, Stine, de Man, Frances S., Nielsen-Kudsk, Jens Erik, Vonk Noordegraaf, Anton   +3 more
core   +1 more source

Prolonged fenfluramine use in open‐label studies of Dravet or Lennox–Gastaut syndromes: Long‐term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness

Epilepsia, EarlyView.
This graphical abstract provides an overview of the content from this open‐label extension study of fenfluramine use in patients with Dravet syndrome or Lennox‐Gastaut syndrome. Abstract Objective Long‐term safety and global functioning are reported in patients with Dravet syndrome (DS) or Lennox–Gastaut syndrome (LGS) treated with fenfluramine in an ...
Antonio Gil‐Nagel, Kelly G. Knupp, Boudewijn Gunning, Domenica Immacolata Battaglia, Elizabeth A. Thiele, Ingrid E. Scheffer, An‐Sofie Schoonjans, Rima Nabbout, Nathalie Villeneuve, Kerstin Alexandra Klotz, Nicola Specchio, Rocio Sanchez‐Carpintero, Marta Zolnowska, Anne‐Liv Schulz, Lily Perrin, Najla Dickson, Mélanie Langlois, Amélie Lothe, Joseph Sullivan   +18 more
wiley   +1 more source

Optimizing polytherapy management for Dravet syndrome in the United States: A National Expert Consensus

Epilepsia Open, EarlyView.
ABSTRACT Objectives Dravet syndrome (DS) is a severe, drug‐resistant developmental and epileptic encephalopathy (DEE) that requires polytherapy for adequate seizure control. The need to combine multiple antiseizure medications (ASMs), together with variability in seizure types, safety considerations, and evolving patient needs, makes treatment ...
Elaine Wirrell, Joseph Sullivan
wiley   +1 more source