Results 141 to 150 of about 1,413,284 (292)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure.
Luca Zazzeron, Kakeru Shimoda, Paul Lichtenegger, Elizabeth Moore, Helena Tattersfield, Alexandra K. Marenco, Jiayi Kang, Haobo Li, Eizo Marutani, Donald B. Bloch, Fumito Ichinose   +10 more
doaj   +1 more source

Risk assessment in medically treated chronic thromboembolic pulmonary hypertension patients

, 2018
Abbreviated versions of the risk stratification strategy of the European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension guidelines have been recently validated in patients with pulmonary arterial hypertension.
Grünig, Ekkehard, Olsson, Karen M., Gruenig, Ekkehard, Staehler, Gerd, Opitz, Christian F., Vonk-Noordegraaf, Anton, Pepke-Zaba, Joanna, Halank, Michael, Klose, Hans, Pittrow, David, Hoeper, Marius M., Gibbs, J. Simon R., Delcroix, Marion, Held, Matthias, Gall, Henning, Rosenkranz, Stephan, Tsangaris, Iraklis, Huscher, Doerte, Lange, Tobias J.   +18 more
core   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Demographic, hemodynamic characteristics, and therapeutic trends of pulmonary hypertension patients: The Pulmonary Hypertension Mexican registry (REMEHIP)

Pulmonary Circulation
Data on demographic characteristics and therapeutic approaches in Latin American pulmonary arterial hypertension (PAH) patients are scarce. Pulmonary Hypertension Mexican registry (REMEHIP) is a multicenter Mexican registry of adult and pediatric ...
Carlos Jerjes‐Sánchez, Alicia Ramírez‐Rivera, Nayeli Zayas Hernandez, Guillermo Cueto Robledo, Humberto García‐Aguilar, Pedro Gutiérrez‐Fajardo, Mario Seoane García de León, Francisco Moreno Hoyos‐Abril, Miguel Ernesto Beltrán Gámez, Jose Elizalde, Tomás Pulido Fccp, Julio Sandoval, The REMEHIP Investigators   +12 more
doaj   +1 more source

Bosentan in Pediatric Patients with Pulmonary Arterial Hypertension

Current Vascular Pharmacology, 2009
In order to provide an overview of current knowledge, the literature was systematically examined for clinical studies, which evaluate the safety and effectiveness of bosentan in pediatric pulmonary arterial hypertension (PAH).3 databases (MEDLINE, EMBASE and BIOSIS) were searched for the period January 2000 - October 2007 using the key words 'pulmonary
openaire   +4 more sources

Current Management of pulmonary Hypertension

, 2018
treatment of pulmonary hypertension. New methods of the new drugs.
Jezawi, Abdullah
core  

Effects of combined angiotensin II receptor antagonism and neprilysin inhibition in experimental pulmonary hypertension and right ventricular failure

, 2019
Background: Combined angiotensin II receptor antagonism and neprilysin inhibition by LCZ696 reduces morbidity and mortality in heart failure patients and works by reducing RAAS activity and increasing cGMP levels.
Nyengaard, Jens Randel, de Man, Frances S., Axelsen, Julie Birkmose, Bogaard, Harm Jan, Ringgaard, Steffen, Nielsen-Kudsk, Jens Erik, Hyldebrandt, Janus Adler, Andersen, A., Andersen, S.   +8 more
core   +1 more source

Study of Risk Factors and Image Findings of Isolated Abdominal Incidentally Detected Aortic Dissection

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 429-435, March/April 2025.
We detect the risk factors and image characteristics of incidentally detected IAAD. Independent risk factors of IAAD included fatty liver and smoking. In the ultrasound findings of IAAD, an intimal flap was frequently observed. In the CT scan, displacement of intimal calcifications was frequently observed. For suspected IAAD, the abdominal aorta should
Hiromasa Tsubouchi, Hidenori Onishi, Koji Maeno, Masaya Nakagaichi, Ikue Tsukushi, Youichi Kitano, Yoshitaka Makino, Hiroyuki Hayashi, Hidekazu Terasawa, Hiroko Kabuto, Toshihiro Misawa, Taku Sanada, Azusa Hisada, Kazuo Notsumata, Kazuhiro Okafuji, Osamu Yamamura   +15 more
wiley   +1 more source

Actigraphy methodology in the Kids Mod PAH trial: Physical activity as a functional endpoint in pediatric clinical trials

Pulmonary Circulation
Pulmonary vasodilator treatment can improve hemodynamics, right ventricular function, symptoms, and survival in pediatric pulmonary hypertension (PH). However, clinical trial data are lacking due to many constraints.
Catherine M. Avitabile, Usha S. Krishnan, Delphine Yung, Stephanie S. Handler, Nidhy Varghese, Angela Bates, Jeff Fineman, Rachel Sullivan, Grace Friere, Eric Austin, Mary P. Mullen, Carol Pereira, Eric J. Christensen, Gayane Yenokyan, Joseph M. Collaco, Steven H. Abman, Lew Romer, D. Dunbar Ivy, Erika B. Rosenzweig   +18 more
doaj   +1 more source