Results 131 to 140 of about 1,413,284 (292)

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Isolated Biventricular Noncompaction in an adult with severe pulmonary hypertension : an association reviewed. [PDF]

, 2012
Biventricular noncompaction is a recently recognized rare form of cardiomyopathy. It is characterized by altered structure of myocardial wall as a result of intrauterine arrest of compaction of the myocardial fibers in absence of coexisting congenital
Awasthy, Neeraj, Tomar, Munesh, Radhakrishnan, Sitaraman   +2 more
core  

Fenfluramine in Rett syndrome: A multidimensional clinical study

Epilepsia Open, EarlyView.
Abstract Objective Rett syndrome (RTT) is a severe neurodevelopmental disorder frequently associated with drug‐resistant epilepsy, autonomic dysfunction, respiratory abnormalities, sleep disturbances, and behavioral impairment. Fenfluramine has shown efficacy in developmental and epileptic encephalopathies and may provide broader therapeutic benefits ...
Elena Gonzalez‐Alguacil, Nuria Lamagrande Casanova, Manuel Luján Bonete, David Mansilla Lozano, Juan José García Peñas, María Ballará Petitbó, Rocío Trincado Lamuño, Verónica Cantarín‐Extremera, Raquel Díaz Conejo, César Rodríguez Sánchez, Adrián García Ron, Víctor Soto Insuga   +11 more
wiley   +1 more source

New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis

, 2012
In spite of treatment, severe angioproliferative pulmonary arterial hypertension (PAH) remains a disease characterized by great morbidity and shortened survival.
Drake, Jennnifer I., Gomez-Arroyo, Jose G., Al Husseini, Aysar, Bogaard, Herman Jan, Mizuno, Shiro, Nicolls, Mark R., Taraseviciene-Stewart, Laima, Voelkel, Norbert F., Farkas, Laszlo   +8 more
core   +1 more source

Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model

, 2020
The pathogenesis of pulmonary arterial hypertension is closely associated with dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition and function were reported in a pulmonary arterial hypertension experimental animal ...
Sakao, Seiichiro, Sanada, Takayuki J., Hosomi, Koji, Miwa, Hideki, Kobayashi, Takayuki, Suda, Rika, Yanagisawa, Asako, Tanabe, Nobuhiro, Shoji, Hiroki, Naito, Akira, Park, Jonguk, Tatsumi, Koichiro, Ikubo, Yumiko, Kunisawa, Jun, Mizuguchi, Kenji   +14 more
core   +1 more source

Identifying Avoidable Emergency Department Visits and the Potential Role of Community Health Centers in Northern Italy: A Retrospective Observational Study

Health Care Science, EarlyView.
Using data from an Italian emergency department (ED), ED visits preventable through integrated community care models (community health centers) were identified. ED visits were classified based on presenting symptoms, comorbidities, medication use, and age.
Silvia Caristia, Isabella Santomauro, Erika Bassi, Laura Ferraris, Alberto Dal Molin, Fabrizio Faggiano   +5 more
wiley   +1 more source

Quality Assessment and Management in Organ Transplantation: A Comparative Analysis of the United States, Germany, and Chinese Mainland

Health Care Science, EarlyView.
Organ transplantation integrates surgery, immunosuppression, training, and quality systems. This analysis compares the United States, Germany, and Chinese Mainland, showing convergence toward data‐driven quality and competency‐based training. Chinese Mainland's centralized model enhances standardization and scalability, while Western systems emphasize ...
Björn Nashan, Miao Pu, Jie Zhao, Haibo Wang   +3 more
wiley   +1 more source

Off-label use of muscular VSD device for closure of a rare congenital portosystemic shunt

The Egyptian Heart Journal
Background Congenital portosystemic shunt (CPSS) is a vascular malformation in which portal blood drains toward the systemic circulation, leading to pulmonary hypertension.
Hala Mounir Agha, Shady Mashoor, Mohamed Ghobashy, Antoine AbdelMassih, Hanya Gaber, Hanaa El-Karaksy   +5 more
doaj   +1 more source

New advances in the treatment of pulmonary hypertension

, 2020
Pulmonary hypertension is a chronic disease with a devastating outcome. It is characterized by remodeling mechanisms that leads to an increase in vascular resistance of the pulmonary arterioles.
Shacham, Mor
core  

New advances in the treatment of pulmonary hypertension

, 2021
New and old agents for the treatment of pulmonary hypertension. The focus is on the novel agents under the investigation of their target and mode of action and their effectiveness for each type of pulmonary hypertension and as well as the promises they ...
Yoon, Adrian Hyeukjin
core