Results 81 to 90 of about 88,848 (322)
Haplotype Inference for Pedigrees with Few Recombinations [PDF]
arXiv, 2016 Pedigrees, or family trees, are graphs of family relationships that are used to study inheritance. A fundamental problem in computational biology is to find, for a pedigree with $n$ individuals genotyped at every site, a set of Mendelian-consistent haplotypes that have the minimum number of recombinations.
arxiv
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Journal of Microbiology & Biology Education, 2017 A card game based upon the classic game Go Fish is presented for active practicing of segregation analysis, the determination of the most likely method of transmission based upon pedigree information. The game is easily prepared and dropped into a classroom setting.
openaire +4 more sources
The Graph of the Pedigree Polytope is Asymptotically Almost Complete (Extended Abstract) [PDF]
arXiv, 2016 Graphs (1-skeletons) of Traveling-Salesman-related polytopes have attracted a lot of attention. Pedigree polytopes are extensions of the classical Symmetric Traveling Salesman Problem polytopes (Arthanari 2000) whose graphs contain the TSP polytope graphs as spanning subgraphs (Arthanari 2013).
arxiv
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Fast Computation of the Kinship Coefficients [PDF]
arXiv, 2016 For families, kinship coefficients are quantifications of the amount of genetic sharing between a pair of individuals. These coefficients are critical for understanding the breeding habits and genetic diversity of diploid populations. Historically, computations of the inbreeding coefficient were used to prohibit inbred marriages and prohibit breeding ...
arxiv
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Fast Genome-Wide QTL Association Mapping on Pedigree and Population Data [PDF]
arXiv, 2014 Since most analysis software for genome-wide association studies (GWAS) currently exploit only unrelated individuals, there is a need for efficient applications that can handle general pedigree data or mixtures of both population and pedigree data. Even data sets thought to consist of only unrelated individuals may include cryptic relationships that ...
arxiv