Results 61 to 70 of about 2,877,555 (301)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Long Dan Xie Gan Formula Granule Promotes Pro-Inflammatory Cytokine Expression in Female Guinea Pigs with Recurrent Genital Herpes

open access: yesDigital Chinese Medicine, 2018
: Objective To explore the effects of Long Dan Xie Gan formula granule (LDXGFG) on regulation of pro-inflammatory cytokines in female guinea pigs with recurrent genital herpes (herpes simplex virus 2, HSV-2).Methods Levels of pro-inflammatory cytokines ...
Lin KUANG   +4 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Muller’s nobel prize research and peer review [PDF]

open access: yesPhilosophy, Ethics, and Humanities in Medicine, 2018
This paper assesses possible reasons why Hermann J. Muller avoided peer-review of data that became the basis of his Nobel Prize award for producing gene mutations in male Drosophila by X-rays.Extensive correspondence between Muller and close associates and other materials were obtained from preserved papers to compliment extensive publications by and ...
openaire   +3 more sources

Preventing rigour mortis: our migration to social media does not spell the end of academic rigour [PDF]

open access: yes, 2012
Academic research involving social media is still perceived as less rigourous than traditional journal publishing. Alan Cann argues that while peer review remains the gold standard for quality research, we must apply this standard to the new unit of ...
Cann, Alan
core  

Two decades of research in L2 peer review [PDF]

open access: yes, 2016
[[notice ...
Chang, Carire Yea-huey
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Online Brazilian Journal of Nursing 2007 Thanks to Peer Reviewers and Authors

open access: yesOnline Brazilian Journal of Nursing, 2007
The editor thanks the OBJN Reviewers and Authors for their competent service during the year 2007.
Isabel CF da Cruz
doaj   +2 more sources

A new twist on peer review

open access: yeseLife, 2018
eLife is conducting a trial in which authors will decide how to respond to the issues raised during peer review.
Mark Patterson, Randy Schekman
doaj   +1 more source

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