Results 51 to 60 of about 58,740,720 (292)

From concept to regulation: OECD’s role in the development of the DNT in vitro battery

Frontiers in Toxicology
Chemical exposure during critical stages of nervous system development can lead to adverse neurotoxic effects, known as developmental neurotoxicity (DNT).
Magdalini Sachana, Helena T. Hogberg, Iris Mangas   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Experimenting with Grant Peer Review: A Mixed Methods Case Study of the Effects on Time Use and the Quality of Reviewing

Publications
Rejection of review invitations due to time constraints is putting pressure on the peer review system, showing that less time-consuming ways of reviewing are needed.
Peter van den Besselaar, Charlie Mom
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

What makes an eLife paper in epidemiology and global health?

eLife, 2015
The best papers provide evidence that can be used to make changes that improve the health and lives of people around the world.
Mark Jit, Eduardo Franco, Prabhat Jha
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Peer review without gatekeeping

eLife, 2022
eLife is changing its editorial process to emphasize public reviews and assessments of preprints by eliminating accept/reject decisions after peer review.
Michael B Eisen, Anna Akhmanova, Timothy E Behrens, Jörn Diedrichsen, Diane M Harper, Mihaela D Iordanova, Detlef Weigel, Mone Zaidi   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

How to Peer Review for Scientific Journals?

International Journal of Advanced Medical and Health Research
Peer review is the evaluation of scientific, academic, or professional work by experts in the field. This process starts when the editor of a peer-reviewed journal sends an article or a manuscript to two or more reviewers for review.
Mukta Wyawahare
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source