Results 61 to 70 of about 2,889,538 (305)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Recognition and reward system for peer-reviewers [PDF]
, 2018 Peer reviewing plays an important role in the academic publishing process that scrutinizes and provides feedback on the scientific work prior to publication.
Jan, Zeeshan
core
Big data techniques in auditing research and practice: Current trends and future opportunities [PDF]
, 2018 This paper analyses the use of big data techniques in auditing, and finds that the practice is not as widespread as it is in other related fields. We first introduce contemporary big data techniques to promote understanding of their potential application.
Gepp, Adrian +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Digital Chinese Medicine, 2018 : Objective To explore the effects of Long Dan Xie Gan formula granule (LDXGFG) on regulation of pro-inflammatory cytokines in female guinea pigs with recurrent genital herpes (herpes simplex virus 2, HSV-2).Methods Levels of pro-inflammatory cytokines ...
Lin KUANG +4 more
doaj +1 more source
Muller’s nobel prize research and peer review [PDF]
Philosophy, Ethics, and Humanities in Medicine, 2018 This paper assesses possible reasons why Hermann J. Muller avoided peer-review of data that became the basis of his Nobel Prize award for producing gene mutations in male Drosophila by X-rays.Extensive correspondence between Muller and close associates and other materials were obtained from preserved papers to compliment extensive publications by and ...
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Should infectious disease modelling research be subject to ethics review?
Philosophy, Ethics, and Humanities in Medicine, 2023 Should research projects involving epidemiological modelling be subject to ethical scrutiny and peer review prior to publication? Mathematical modelling had considerable impacts during the COVID-19 pandemic, leading to social distancing and lockdowns ...
Ben Green
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Research papers, gender bias and peer-review [PDF]
Biology Letters, 2017 Following our 2017 Editorial Board meeting in April and with the first half of 2017 now passed, I am delighted to provide our readers with an update on how Biology Letters is progressing. At the time of writing, we have so far this year published 92 papers and completed two Special Features ...
openaire +2 more sources