Results 41 to 50 of about 894,999 (265)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cooperation & Liaison between Universities & Editors (CLUE): recommendations on best practice
Research Integrity and Peer Review, 2021 Background Inaccurate, false or incomplete research publications may mislead readers including researchers and decision-makers. It is therefore important that such problems are identified and rectified promptly.
Elizabeth Wager +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
How to Peer Review for Scientific Journals?
International Journal of Advanced Medical and Health ResearchPeer review is the evaluation of scientific, academic, or professional work by experts in the field. This process starts when the editor of a peer-reviewed journal sends an article or a manuscript to two or more reviewers for review.
Mukta Wyawahare
doaj +1 more source
Digital Chinese Medicine, 2018 : Objective Identification of one’s constitution based on a combination of features and back propagation neural network theory is needed in modern medicine and traditional Chinese medicine (TCM).
Yue Luo +3 more
doaj +1 more source
Peer review without gatekeeping
eLife, 2022 eLife is changing its editorial process to emphasize public reviews and assessments of preprints by eliminating accept/reject decisions after peer review.
Michael B Eisen +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2023 Peer review is a quality control mechanism in scholarly research. Most usage refers to a process in which after a paper has been submitted to a journal - an editor of that journal invites independent (external) experts to evaluate that work and provide advice on how the paper could be improved before it is published and shared with the world.
openaire +1 more source
Using democracy to award research funding: an observational study
Research Integrity and Peer Review, 2017 Background Winning funding for health and medical research usually involves a lengthy application process. With success rates under 20%, much of the time spent by 80% of applicants could have been better used on actual research.
Adrian G. Barnett +3 more
doaj +1 more source