Results 71 to 80 of about 519,096 (286)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Quantifying the quality of peer reviewers through Zipf's law
, 2015 This paper introduces a statistical and other analysis of peer reviewers in order to approach their "quality" through some quantification measure, thereby leading to some quality metrics.
Ausloos, Marcel +3 more
core +1 more source
Effects of climate extremes on the terrestrial carbon cycle : concepts, processes and potential future impacts [PDF]
, 2015 This article is protected by copyright. All rights reserved. Acknowledgements This work emerged from the CARBO-Extreme project, funded by the European Community’s 7th framework programme under grant agreement (FP7-ENV-2008-1-226701).
Babst, Flurin +23 more
core +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Resourcefulness, Desperation, Shame, Gratitude and Powerlessness : Common Themes Emerging from A Study of Food Bank Use in Northeast Scotland [PDF]
, 2015 Acknowledgements This study received funding support from the Scottish Government’s Rural and Environment Science and Analytical Services (RESAS), Theme 7 ‘Healthy Safe Diets’ Research Programmed.
Flora Douglas +4 more
core +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Serving as a Peer Reviewer: Rewards and Challenges [PDF]
, 2016 The practice of peer review is essential to ensure academic quality of articles published in professional journals. Nurses with expertise in evidence-based best practices are often well-qualified to serve as peer reviewers.
Abell, Cathy H. +1 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source