Results 61 to 70 of about 3,707 (198)

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, Volume 12, Issue 39, October 20, 2025.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects [PDF]

, 2015
Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines.
Asadi-Samani, Majid., Aslani, Elahe., Kooti, Wesam., shirzad, Hedayatollah.   +3 more
core   +1 more source

The Effect of Alkanna tincturia and Peganum harmala Extracts on Leishmania major (MRHO/IR/75/ER) in vitro [PDF]

Iranian Journal of Parasitology, 2009
"nBackground: Cutaneous leishmaniasis is an important health problem caused by Leishmania spp. As there is no vaccine, drug treatment is the only way to tackle leishmaniasis.
Fatemeh Ghaffarifar, Abdolhosein Dalimi Asl, Ruhallah Yousefi   +2 more
doaj   +2 more sources

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni, Milena Costa Bassicheto, Maria Vitória de Oliveira, Ana Beatriz dos Santos de Souza, Gabriella Melo Alves, Thiago André Moura Veiga   +5 more
wiley   +1 more source

بررسی سميت سلولی عصاره دانه گياه اسفند و ارتباط آن با ميزان آلکالوئيدهای بتا ـ کاربولينی موجود در عصاره [PDF]

, 2002
عصاره دانه گياه اسفند ( Peganum harmala L. ) از جمله اجزای تشکيل دهنده يکی از فرآورده‌های گياهی بومی بکار رفته جهت درمان سرطان در ايران است. آلکالوئيدهای بتا ـ کاربولينی نظير هارمين و هارمالين قسمت اعظم ترکيبات فعال موجود در اسفند را تشکيل می‌دهند.
احمد ابراهيمی, سلطان, رهبر روشندل, ناهید, محموديان, مسعود, مددکارسبحانی, آرمین, هورمند, محمود   +4 more
core  

Alcaloides en la flora de Andalucia, I [PDF]

, 1988
Se han estudiado 106 especies vegetales características de la flora de Andalucía con objeto de determinar la presencia cualitativa y cuantitativa de alcaloides. Se ha encontrado presencia de alcaloides en 37 especies, de las cuales 20 (54 0) se describen
Cabezudo, Baltasar, García, Ana I., Nieto-Caldera, Jose Maria, Rico, Rodrigo, Salvo-Tierra, Angel Enrique, Suau, Rafael   +5 more
core   +4 more sources

PERSPECTIVE DRUG DOSAGE OF NEUTROPIC REMEDY ON THE BASIS OF EXCIPIENT FROM ROOTS OF PEGANUM HARMALA L.

Фармация и фармакология (Пятигорск), 2015
This article represents the results of technological researches on development of new neurotropic remedy based on water-soluble excipient of harmine hydrochloride.
H. I. Itzhanova, Zh. S. Nurmaganbetov, A. S. Mukazhanova, A. Zh. Turmukhambetov, S. M. Adekenov   +4 more
doaj   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Alleviation of Boron Stress through Plant Derived Smoke Extracts in Sorghum bicolor [PDF]

, 2014
Boron is an essential micronutrient necessary for plant growth at optimum concentration. However, at high concentrations boron affects plant growth and is toxic to cells.
M.A. Waheed, Memoona Kanwal, Muhammad Jamil, Muhammad Mudassar Aslam, Pirzada Khan, Shafiq ur Rehman, Shahid Irfan, Shakirullah Khan Shakir   +7 more
core  

Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens [PDF]

, 2014
Agricultural intensification typically has detrimental effects on pollinator communities, but diverse cropping systems that contain sequentially-flowering crops have the potential to benefit pollinators through the provision of additional floral ...
A Gotlieb, A Holzschuh, A Holzschuh, A Zuur, AA Ormsby, C Dormann, C Mayer, CFJF Dormann, CM Kennedy, CR Archer, D Jose, ECM Fernandes, Francis Gilbert, H Gilbert, I Steffan-Dewenter, J Cools, JH Cane, JM Kasina, KC Matteson, L Boulos, L Maffi, LA Dyer, LA Garibaldi, LG Horlings, Markus P. Eichhorn, MJO Pocock, MO Hill, N Gallai, NJ Gotelli, O Norfolk, O Norfolk, O Norfolk, Olivia Norfolk, R Development Core Team, R Rosa García, S Barthel, S Zalat, SS Greenleaf, T Tscharntke, U Samnegård, V Féon Le   +40 more
core   +2 more sources