Results 1 to 10 of about 8,983 (134)

A Pegylated Liposomal Platform: Pharmacokinetics, Pharmacodynamics, and Toxicity in Mice Using Doxorubicin as a Model Drug

Journal of Pharmacological Sciences, 2004
Aims were to observe pharmacokinetics, pharmacodynamics, and toxicity for constructing a Sino-pegylated liposomal platform. Human hepatocarcinoma cells (Bel7402) and murine hepatocarcinoma cells (H22) were used for the cytotoxicity assay and the in vivo ...
Wan-Liang Lu, Xian-Rong Qi, Qiang Zhang   +2 more
exaly   +3 more sources

Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin [PDF]

Nature Communications
Intrahepatic accumulation dominates organ distribution for most nanomedicines. However, obscure intrahepatic fate largely hampers regulation on their in vivo performance.
Kuan Jiang, Kaisong Tian, Yifei Yu, Ercan Wu, Min Yang, Feng Pan, Jun Qian, Changyou Zhan   +7 more
doaj   +2 more sources

Diffuse Erythematous Follicular Eruption Induced by Pegylated Liposomal Doxorubicin [PDF]

Clinical, Cosmetic and Investigational Dermatology
Lingzhi Zhong,* Jian Hu,* Yuqing Hu, Xue Chen, Jiang Jin, Houmin Li Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Houmin Li ...
Zhong L, Hu J, Hu Y, Chen X, Jin J, Li H
doaj   +2 more sources

The use of pegylated liposomal doxorubicin in metastatic soft tissue sarcoma [PDF]

Acta Oncologica
Background: Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with limited response to conventional chemotherapy. Among these, epithelioid haemangioendothelioma (EHE) and angiosarcoma represent rare vascular sarcomas with distinct ...
Trang Pham, Hanne Krogh Rose, Philip Rossen, Ninna Aggerholm Pedersen   +3 more
doaj   +2 more sources

Successful avatrombopag combined with cyclosporine treatment for carboplatin/pegylated liposomal doxorubicin/bevacizumab-induced acquired amegakaryocytic thrombocytopenia in a patient with recurrent ovarian cancer: case report [PDF]

Frontiers in Oncology
Carboplatin/pegylated liposomal doxorubicin/bevacizumab is an accepted standard anti-cancer treatment option for recurrent ovarian cancer. However, the occurrence of adverse events associated with this therapeutic regimen limits its continued clinical ...
Weikang Meng, Jinsheng Hua, Jiabing Wang
doaj   +2 more sources

Pegylated Liposomal Doxorubicin and Kidney-Limited Thrombotic Microangiopathy in a Kidney Transplant Recipient: A Case Report

Kidney Medicine, 2022
A 64-year-old man with Kaposi sarcoma in clinical remission after treatment with pegylated liposomal doxorubicin and a history of deceased-donor kidney transplantation 4 years prior presented with a slowly progressive increase in his serum creatinine ...
Sonia Rodriguez-Ramirez, Kevin Yau, Abhijat Kitchlu, Rohan John, April A.N. Rose, David Hogg, S. Joseph Kim   +6 more
doaj   +1 more source

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. [PDF]

PLoS ONE, 2013
The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as ...
Stefano Toldo, Rachel W Goehe, Marzia Lotrionte, Eleonora Mezzaroma, Evan T Sumner, Giuseppe G L Biondi-Zoccai, Ignacio M Seropian, Benjamin W Van Tassell, Francesco Loperfido, Giovanni Palazzoni, Norbert F Voelkel, Antonio Abbate, David A Gewirtz   +12 more
doaj   +1 more source

Minibeam radiation therapy enhanced tumor delivery of PEGylated liposomal doxorubicin in a triple-negative breast cancer mouse model

Therapeutic Advances in Medical Oncology, 2021
Background: Minibeam radiation therapy is an experimental radiation therapy utilizing an array of parallel submillimeter planar X-ray beams. In preclinical studies, minibeam radiation therapy has been shown to eradicate tumors and cause significantly ...
Lauren S.L. Price, Judith N. Rivera, Andrew J. Madden, Leah B. Herity, Joseph A. Piscitelli, Savannah Mageau, Charlene M. Santos, Jose R. Roques, Bentley Midkiff, Nana N. Feinberg, David Darr, Sha X. Chang, William C. Zamboni   +12 more
doaj   +1 more source

PEGylated Liposomal Doxorubicin Rechallenge following Doxorubicin-induced Pancreatitis

Current Problems in Cancer: Case Reports, 2020
Drug induced pancreatitis is rare and establishing the exact causal relationship is challenging. Here, we discuss the management of a 60 year-old female patient with stage 3a breast cancer who developed doxorubicin induced pancreatitis 3 days after her ...
Luke Ardolino, Eugene Moylan
doaj   +1 more source

Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin [PDF]

Anais Brasileiros de Dermatologia, 2015
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin.
Han Ma, Meilan Chen, Junru Liu, Ying Li, Juan Li   +4 more
doaj   +1 more source