Results 161 to 170 of about 31,898 (250)

Site-Specific PEGylation at Residue 86 Improves Pharmacokinetic Properties of Interferon α-2b. [PDF]

Iran J Biotechnol
Alboshokeh MA, Mirshekar S, Hedayati MH, Gholami A, Javdani Shahedin G, Arabi Mianroodi R.   +5 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Site- and Size-Controlled PEGylation Modulates Biointerfaces and Immunoregulatory Functions of Bifunctional Peptides in an Autoimmune Disease Model. [PDF]

ACS Appl Mater Interfaces
Song SJ, Villela Nava AL, Xie J, Li X, Siahaan TJ, Kim H.   +5 more
europepmc   +1 more source

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Mechanistic Insights Into the Retention and Separation Mechanism of Poly(Ethylene Glycol)-Modified Short Oligonucleotides in Anion-Exchange Chromatography. [PDF]

Biotechnol J
Yoshimoto N, Matsumoto T, Ono Y, Kumagai Y.   +3 more
europepmc   +1 more source

Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell‐Specific Uptake Determinants in Human Immune Cell Subsets

Small Science, Volume 6, Issue 3, March 2026.
This study examines how the physico‐chemical properties of gold nanorods (AuNR) influence their interactions with human immune cells. Antibody‐targeted AuNR selectively bind and induce apoptosis in T‐lymphocytes during photothermal therapy. In contrast, neutrophils have a high intrinsic phagocytic capacity and the design of selective particles requires
Tista Roy Chaudhuri, Helene Giesler, Marija Kovacevic Sarmiento, Kim Lamers, Michelle Hechler, Michael Erkelenz, Marvin Haferkamp, Ronja Schirrmann, Milen Nachev, Rebeka Bosnjakovic, Bernd Sures, Sebastian Schlücker, Sven Brandau   +12 more
wiley   +1 more source

PEGylation Overcomes Pharmacological Barriers to Improve Systemic Pharmacokinetics and Therapeutic Efficacy of Phages against MDR <i>Escherichia coli</i>. [PDF]

J Microbiol Biotechnol
Shamsuzzaman M, Choi YJ, Kim S, Jeong JY, Hong CA, Kim J.   +5 more
europepmc   +1 more source

Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers

Small Structures, Volume 7, Issue 3, March 2026.
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis, Lauren A. Lowe, Jingyi Yao, Zhenxu Yang, Shaoxue Zeng, Ken‐Tye Yong, Ling Zhu, Yi Shen   +7 more
wiley   +1 more source

Pegylated Paclitaxel [PDF]

, 2020
openaire   +1 more source

PEGylation agents

Drug Delivery System, 2015
Yutaka Ikeda, Yukio Nagasaki
openaire   +2 more sources