Results 51 to 60 of about 15,208 (279)

Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity

OncoImmunology
Prostate cancer (PCa) is characterized as a “cold tumor” with limited immune responses, rendering the tumor resistant to immune checkpoint inhibitors (ICI).
Zhen Xu, Ze-Xiu Xiao, Jing Wang, Hao-Wei Qiu, Fei Cao, Shi-Qiang Zhang, Yuan-Dong Xu, Han-Qi Lei, Heng Xia, Yun-Ru He, Gao-Feng Zha, Jun Pang   +11 more
doaj   +1 more source

Association between pelvic floor muscle strength and sexual function based on PISQ-12—an analysis of data from a multicenter cross-sectional study on 735 nulliparae during pregnancy

Frontiers in Medicine, 2023
BackgroundPelvic floor muscle strength is well-known to be associated with female sexual function. However, there were a few studies that reported on the relationship between pelvic floor muscle strength and female sexual function in pregnant women, and ...
Lei Gao, Lei Gao, Bing Xie, Bing Xie, Hongmei Zhu, Hongmei Zhu, Hongmei Zhu, Di Zhang, Di Zhang, Xiuhong Fu, Xiuhong Fu, Hongjuan Li, Min Zhen, Baoling Qin, Weipeng Chen, Xuying Mao, Lingrui Kong, Jianliu Wang, Jianliu Wang, Guizhu Wu, Xiuli Sun, Xiuli Sun   +21 more
doaj   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

Journal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella, Hiruni Jayasena, Prathibha Wijesingha, Janaka de Silva   +3 more
wiley   +1 more source

Differential Effects of Levodopa and Stimulation on Post‐Surgery Freezing of Gait in Subthalamic Nucleus Deep Brain Stimulation Parkinson's Disease Patients: A Clinical and Kinematic Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The long‐term efficacy of high‐frequency subthalamic nucleus deep brain stimulation (STN‐DBS) on freezing of gait (FOG) remains unclear. We aimed to study the mechanism and optimal therapeutic approach to long‐term post‐surgery FOG.
Raquel Barbosa, Paulo Bastos, Patrícia Pita Lobo, Catarina Correia Rodrigues, Anabela Valadas, Leonor Correia Guedes, Beatriz Mano, Sara Alberto, Vitor Paixão, Mário Miguel Rosa, Ricardo Matias, Daniel Martins, Marcelo Mendonça, Miguel Coelho   +13 more
wiley   +1 more source

Interstitial Cystitis/Bladder Pain Syndrome Patient Phenotyping

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April of 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on IC/BPS in Winston‐Salem, NC. The goal of this meeting was to establish global consensus regarding diagnostic criteria, phenotyping, treatment outcome assessment, and etiopathology in interstitial cystitis/bladder pain syndrome (IC ...
Dylan T. Wolff, Stephen Tranchina, Andrew Schrepf, R. Christopher Doiron, Toby C. Chai, Stephen J. Walker   +5 more
wiley   +1 more source

Association of cigarette use with risk of prostate cancer among US males: a cross-sectional study from NHANES 1999–2020

BMC Public Health
Background Association of cigarette use with risk of prostate cancer remains unclear. We performed this study to examine whether cigarette use is associated with increased risk of prostate cancer.
Xiangwei Yang, Hong Chen, Junfu Zhang, Shiqiang Zhang, Yongda Socrates Wu, Jun Pang   +5 more
doaj   +1 more source

Development Ideas for the Multidisciplinary Integrative Diagnosis and Treatment System of Pelvic Floor Medicine

Chinese Medicine and Culture, 2020
With the rapid growth of the aging population, pelvic floor dysfunction (PFD) has become a new type of high-incidence disorder. This disorder can be caused by injury, functional deterioration, or coordination disorders of pelvic support structures, such ...
Haidong Wang
doaj   +1 more source

Role of Gynecologic Findings in Interstitial Cystitis/Bladder Pain Syndrome: A Consensus

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To evaluate the role of gynecologic findings in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by reviewing current international guidelines and identifying relevant gynecologic co‐morbidities. Methods This consensus statement was developed through a systematic four‐phase process: (1) comprehensive literature review across ...
Marie E. Sullivan, Amr El Haraki, Anna Padoa, Katy Vincent, Kristene E. Whitmore, Mauro Cervigni   +5 more
wiley   +1 more source

Interstitial Cystitis/Bladder Pain Syndrome in Men

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on interstitial cystitis/bladder pain syndrome (IC/BPS) in Winston‐Salem, NC. The goal of this meeting was to establish attainable targets in phenotyping, diagnosis, and biomarkers for IC/BPS.
Madeline Snipes, Wyatt Whitman, Michel Pontari, Jennifer Anger, Michael Samarinas, Rajesh Taneja   +5 more
wiley   +1 more source

Patient Related Outcomes for Interstitial Cystitis/Bladder Pain Syndrome Recommendations for Clinical Trials and General Urology Practice

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction The goal of this committee of the Interstitial Cystitis/Bladder Pain (IC/BPS) Consensus Group was to address the use of patient related outcomes (PROs) in IC/BPS. Methods Priority areas of concern and related PICO (Population, Intervention, Comparison, Outcome) questions were addressed based on literature review, committee ...
Byron Hayes, Mary Namugosa, Robert J. Evans, Sakineh Hajebrahimi, Dick Janssen, Claudia King, Sanjay Pandey, J. Curtis Nickel   +7 more
wiley   +1 more source