Results 161 to 170 of about 186,761 (273)

Advancements in the utilization of immune checkpoint inhibitors for the treatment of gynecological tumors. [PDF]

Front Immunol
Su Z, Zhang X, Xu J, Shen Y.
europepmc   +1 more source

Basal cell carcinoma: Management of advanced or metastatic cancer with checkpoint inhibitors and concurrent paradoxical development of new superficial tumors. [PDF]

, 2020
Cohen, Philip R, Kurzrock, Razelle
core   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

A Single Dose Study of Pembrolizumab in People With HIV Infection Who are Immunologic Nonresponders. [PDF]

Open Forum Infect Dis
Kuruppu J, Purdy JB, Pauls C, Rogan DC, Blazkova J, Kardava L, Sewack AB, Proschan MA, Migueles SA, Connors M, Webber JD, Meeks T, Przygonska PA, Adelsberger JW, Higgins J, Rupert A, Moir SL, Chun TW, Lane HC, Kovacs JA.   +19 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Pembrolizumab Experience in a Patient with Progressive Multifocal Leukoencephalopathy Following Multiple Myeloma Treatment: A Case Report and Literature Review. [PDF]

Noro Psikiyatr Ars
Yıldız MS, Maharramov E, Yıldız FG, Tan E, Özen NPA, Göçmen R, Tuncer A.   +6 more
europepmc   +1 more source

A general and green approach of pH‐sensitive ZIF‐67 for encapsulating active substances

Smart Molecules, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) was successfully synthesized in deionized water for 2 h in this work; meanwhile, various active substances could be encapsulated in one‐pot with the same process, resulting in high loading rates. The study delved into the growth mechanism, morphological difference and loading capacity.
Xinyi Sun, Yan Qi, Xinhao Che, Lulu Zhou, Yuxin Li, Lei Zhang, Jing Hu   +6 more
wiley   +1 more source

The Keynote-177 Randomized Controlled Trial of First-line PD-1 Blockade for Microsatellite-High or Mismatch Repair-Deficient Advanced Colorectal Cancer: Potential Consequences of the Cross-Over Trial Design and Related Issues. [PDF]

Cancer Med
Gerritse SL, van Meerten E, Duits AJ, Schnog JB.   +3 more
europepmc   +1 more source

Inflammatory Markers‐Based Surgical Pathological Complete Response Prediction After Neoadjuvant Immunotherapy Combined With Chemotherapy in Head and Neck Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the predictive value of blood routine parameters for surgical pathological complete response (PCR) following neoadjuvant immunotherapy combined with chemotherapy (NICC) in patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC).
Yu‐Dong Ning, Yi‐Xuan Song, Han Li, Yu‐Qin He, Shao‐Yan Liu   +4 more
wiley   +1 more source

Systemic AL (λ) Amyloidosis Discovered After Neoadjuvant Pembrolizumab-Based Chemoimmunotherapy for Resectable NSCLC: Case Report. [PDF]

Respirol Case Rep
Ma W, Ferrari-Light DM, Lu L.
europepmc   +1 more source