Long-Term Response to Pembrolizumab in Metastatic Metaplastic Breast Carcinoma: A Case Report. [PDF]
Oshima Y +7 more
europepmc +1 more source
ABSTRACT Objective To explore the predictive value of blood routine parameters for surgical pathological complete response (PCR) following neoadjuvant immunotherapy combined with chemotherapy (NICC) in patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC).
Yu‐Dong Ning +4 more
wiley +1 more source
Indirect Comparison of the Efficacy of Pembrolizumab Versus Nivolumab as Adjuvant Options for Stage IIB/IIC Melanoma. [PDF]
Andreikos DA +8 more
europepmc +1 more source
ABSTRACT Introduction Transoral robotic surgery (TORS) and radiotherapy are both recognised as effective treatment options for early‐stage HPV‐associated oropharyngeal squamous cell carcinoma (HPV‐OPSCC). TORS offers the benefit of a shorter total treatment duration; however, a proportion of patients require adjuvant radiotherapy with or without ...
Lan Gao +3 more
wiley +1 more source
Checkpoint inhibitors in microsatellite instability-high metastatic colorectal cancer: treatment strategies, specificities, and care management questions. [PDF]
André T +4 more
europepmc +1 more source
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski +7 more
wiley +1 more source
Pembrolizumab-Induced Isolated Adrenocorticotropic Hormone (ACTH) Deficiency
Pembrolizumab is a programmed death 1 receptor (PD-1) inhibitor. It is used as immunotherapy in various cancers, including metastatic melanoma, non-small cell lung cancer, and, notably, high-risk triple-negative breast cancer.
Han, Hye Jeong, Alfares, Khalid
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Predictors of pathologic complete response in early-stage triple-negative breast cancer treated with neoadjuvant chemo-immunotherapy: a multi-institution study. [PDF]
LeVee A +8 more
europepmc +1 more source
Benchmarked Colorectal Cancer Outcomes in a Metropolitan Hospital: A 5‐Year Review
In metastatic disease, patients with lung‐only metastasis had the best 5‐year survival at 46.0% and curative‐intent approaches can dramatically improve survival. ABSTRACT Introduction Colorectal cancer (CRC) remains a major contributor to cancer‐related mortality worldwide, with survival influenced by many prognostic factors.
Jialin Du +3 more
wiley +1 more source
Pembrolizumab plus enfortumab vedotin in urothelial cancer
The combination of pembrolizumab and enfortumab vedotin shows promise as a first-line therapy for advanced urothelial carcinoma. Enfortumab vedotin targets nectin-4, in turn enhancing T cell and natural killer cell activity, inhibiting immunosuppressive ...
Fiala, Ondrej +9 more
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