Results 171 to 180 of about 198,039 (308)

Brain Freeze: Pembrolizumab-Induced Autoimmune Encephalitis in Triple-Negative Breast Cancer [PDF]

Shanu Modi, Charishma Bhimineni, Malay Rathod, Danielle Palaferro, Minal Dhamankar   +4 more
openalex   +1 more source

Non-bacterial cystitis secondary to pembrolizumab: A case report and review of the literature

, 2022
Xing He, Rongfang Tu, Saili Zeng, Zhenhua He, Sha Liu, Yong Fang   +5 more
openalex   +1 more source

924P Polyfunctional HPV16-Specific T cell responses in subjects receiving PDS0101 and pembrolizumab combination treatment for recurrent/metastatic HPV16-positive head and neck squamous cell carcinoma (HNSCC) [PDF]

, 2023
Kevin J. Harrington, J. Weiß, Katharine A. Price, John M. Kaczmar, David Schaaf, N. Riebel, Sarah Jones, A. Cotty, S.G. McCarthy, L.V. Wood   +9 more
openalex   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Exploring Pembrolizumab-Induced IM3OS in a Patient With Bladder Cancer. [PDF]

Pharmacol Res Perspect
Chan CC, Lee MJ, Su J, Su JJ.
europepmc   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

A cost-effectiveness analysis comparing pembrolizumab combined with chemotherapy versus chemotherapy alone for advanced biliary tract cancer: US and China perspectives. [PDF]

PLoS One
Zhang C, Liang H, Qin Y, Tan X, Su X, Tian X, Nong Y.   +6 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Conversion Surgery for Advanced Gastric Cancer with Para-Aortic Lymph Node Metastases Following Treatment with Capecitabine, Oxaliplatin, and Pembrolizumab: A Case Report. [PDF]

Surg Case Rep
Ono T, Waki Y, Takamoto M, Tokuda K, Sato K, Horiuchi A.   +5 more
europepmc   +1 more source

Remarkable response to pembrolizumab in PD-L1 overexpressing (≥ 50%) NSCLC and extracranial abscopal effect induced by brain radiotherapy: a case report [PDF]

Yong Xia, Hongfan Zhu, Sheng‐Teng Huang, Xinhong Guan, Xudong Chen, Qian Zhang, Meng Liu, Hui Xue, Haiyan Xiang, Shengli Lai, Jinxing Lou   +10 more
openalex   +1 more source