Results 11 to 20 of about 68,185 (326)

Epidemiology of Pemphigus

JID Innovations, 2021
Pemphigus is an epidemiologically heterogeneous group of autoimmune bullous diseases comprising pemphigus vulgaris (PV), pemphigus foliaceus, paraneoplastic pemphigus, IgA pemphigus, and pemphigus herpetiformis.
Khalaf Kridin, Enno Schmidt
doaj   +2 more sources

An Updated Review of Pemphigus Diseases

Medicina, 2021
Clinicians may encounter a variety of skin conditions that present with vesiculobullous lesions in their everyday practice. Pemphigus vulgaris, pemphigus foliaceus, IgA pemphigus, and paraneoplastic pemphigus represent the spectrum of autoimmune bullous ...
Ali M. Malik, Sarah Tupchong, Simo Huang, Abhirup Are, Sylvia Hsu, Kiran Motaparthi   +5 more
doaj   +2 more sources

Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy [PDF]

International Journal of Molecular Sciences, 2017
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients.
Andrea Ciofalo, Biagio Didona, Bialy-Golan, Dario Didona, Elisa Moliterni, Giannicola Iannella, Giovanni Paolino, Giuseppe Magliulo, Guido Granata, Hainsworth, Martínez De Pablo, Matz, Michele Donati, Mutasim, Nguyen, Patricia Ranuzzi, Santo Mercuri, Schepens, Stefano Calvieri, Su, Vincenzo Falasca, Zimmermann   +21 more
core   +3 more sources

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1).
Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli   +6 more
doaj   +2 more sources

Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus

Nature Communications, 2023
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament ...
A. Sigmund, Markus Winkler, Sophia Engelmayer, D. Kugelmann, D. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermaier, M. Radeva, Franziska C. Bayerbach, Elisabeth S. Butz, Stefan Kotschi, C. Hudemann, M. Hertl, Sunil Yeruva, E. Schmidt, A. Yazdi, K. Ghoreschi, Franziska Vielmuth, J. Waschke   +19 more
semanticscholar   +1 more source

Pemphigus: trigger and predisposing factors

Frontiers in Medicine, 2023
Pemphigus is a life-threatening autoimmune blistering disease affecting skin and mucous membranes. Despite its etiopathogenesis remains largely unknown, several trigger and predisposing factors have been reported.
F. Moro, J. L. Sinagra, A. Salemme, L. Fania, F. Mariotti, A. Pira, B. Didona, G. Di Zenzo   +7 more
semanticscholar   +1 more source

Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: a phase II multicentre, open‐label feasibility trial *

British Journal of Dermatology, 2021
Pemphigus vulgaris and pemphigus foliaceus are potentially life‐threatening autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal desmogleins. There is an unmet need for fast‐acting drugs that enable patients to achieve early
M. Goebeler, Z. Bata-Csörgő, C. De Simone, B. Didona, É. Remenyik, N. Reznichenko, J. Stoevesandt, E. Ward, W. Parys, H. Haard, P. Dupuy, P. Verheesen, E. Schmidt, P. Joly   +13 more
semanticscholar   +1 more source

S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid: 2019 update

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020
(1) Department of Dermatology, University of Lübeck, Lübeck, Germany (2) Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany (3) Department of Dermatology, University Hospital Erlangen, Erlangen, Germany (4) Department of ...
Enno Schmidt, M. Sticherling, Miklós Sárdy, Rüdiger Eming, M. Goebeler, M. Hertl, Silke C. Hofmann, N. Hunzelmann, J. Kern, Harald Kramer, A. Nast, H. Orzechowski, Christiane Pfeiffer, V. Schuster, C. Sitaru, M. Zidane, D. Zillikens, M. Worm   +17 more
semanticscholar   +1 more source

Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV)

Journal of the European Academy of Dermatology and Venereology, 2020
Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin. Before the era of immunosuppressive treatment, pemphigus was almost always fatal.
P. Joly, Barbara Horváth, Α. Patsatsi, S. Uzun, R. Bech, Stefan Beissert, Reuven Bergman, Philippe Bernard, L. Borradori, M. Caproni, F. Caux, G. Cianchini, M. Daneshpazhooh, D. De, M. Dmochowski, K. Drenovska, J. Ehrchen, Claudio Feliciani, Matthias Goebeler, R. Groves, C. Guenther, Silke C. Hofmann, D. Ioannides, C. Kowalewski, R. Ludwig, Y. L. Lim, B. Marinović, A. Marzano, A. Marzano, J. Mascaró, D. Mimouni, D. Murrell, C. Pincelli, C. P. Squarcioni, Miklós Sárdy, J. Setterfield, Eli Sprecher, Eli Sprecher, S. Vassileva, K. Woźniak, S. Yaylı, G. Zambruno, D. Zillikens, M. Hertl, Enno Schmidt   +44 more
semanticscholar   +1 more source

Proof of concept for the clinical effects of oral rilzabrutinib, the first Bruton tyrosine kinase inhibitor for pemphigus vulgaris: the phase II BELIEVE study

British Journal of Dermatology, 2021
Bruton tyrosine kinase (BTK) inhibition targets B‐cell and other non‐T‐cell immune cells implicated in the pathophysiology of pemphigus, an autoimmune disease driven by anti‐desmoglein autoantibodies.
D. Murrell, A. Patsatsi, P. Stavropoulos, S. Baum, T. Zeeli, J. Kern, A. Roussaki-Schulze, R. Sinclair, I. Bassukas, D. Thomas, A. Neale, P. Arora, F. Caux, V. Werth, S. Gourlay, P. Joly   +15 more
semanticscholar   +1 more source