Results 21 to 30 of about 68,185 (326)
Autoantibody-Specific Signalling in Pemphigus
Frontiers in Medicine, 2021 Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion.
T. Schmitt, J. Waschke
semanticscholar +1 more source
Dental Clinics of North America, 2013 Pemphigus vulgaris and paraneoplastic pemphigus are 2 subtypes of pemphigus that involve the oral mucosa. These autoimmune blistering disorders have antibodies targeted against proteins of keratinocyte adhesion, thereby causing acantholysis. Clinical findings include oral erosions and flaccid cutaneous bullae and erosions.
Stoopler, Eric T +2 more
openaire +3 more sources
Comprehensive review on the pathophysiology, clinical variants and management of pemphigus (Review)
Experimental and Therapeutic Medicine, 2021 Pemphigus represents a group of chronic inflammatory disorders characterized by autoantibodies that target components of desmosomes, leading to the loss of intercellular adhesion between keratinocytes and causing intraepithelial blistering. The pemphigus
V. Costan +4 more
semanticscholar +1 more source
Post-Pemphigus Acanthomata Presenting as an Isolated, Hyperkeratotic Plaque
Dermatopathology, 2023 Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally,
Rachita Pandya +4 more
doaj +1 more source
Pemphigus and Pemphigoid: From Disease Mechanisms to Druggable Pathways.
Journal of Investigative Dermatology, 2021 Pemphigus and pemphigoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans. In pemphigus, IgG4-predominant autoantibodies cause intraepidermal blistering by direct interference with desmoglein interactions ...
C. Ellebrecht, Damian Maseda, A. Payne
semanticscholar +1 more source
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Autoimmune diseases and their manifestations on oral cavity: diagnosis and clinical management [PDF]
, 2018 Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies.
Bossù, Maurizio +5 more
core +2 more sources
Autoimmune bullous skin diseases, pemphigus and pemphigoid.
Journal of Allergy and Clinical Immunology, 2020 Autoimmune bullous skin diseases, such as pemphigus and pemphigoid, may enable clarification of the mechanisms of immune regulation in the skin. Pemphigus and pemphigoid are mediated by essentially IgG autoantibodies against structural proteins of the ...
S. Egami, J. Yamagami, M. Amagai
semanticscholar +1 more source
Journal of Investigative Dermatology, 2021 Pemphigus is a debilitating immunoglobulin G (IgG)-mediated autoimmune disease in need of better tolerated, more targeted and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor (FcRn) interactions with IgG.
V. Werth +8 more
semanticscholar +1 more source
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +9 more
core +1 more source