Results 161 to 170 of about 5,901 (191)
Hepatic PEMT Expression Decreases with Increasing NAFLD Severity
International Journal of Molecular Sciences, 2022 Choline deficiency causes hepatic fat accumulation, and is associated with a higher risk of nonalcoholic fatty liver disease (NAFLD) and more advanced NAFLD-related hepatic fibrosis. Reduced expression of hepatic phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the production of phosphatidylcholine, causes steatosis, inflammation ...
Janith Heendeni Pathiranage Don +2 more
exaly +6 more sources
International Journal of Molecular Sciences, 2023 The hepatitis C virus (HCV) relies on cellular lipid pathways for virus replication and also induces liver steatosis, but the mechanisms involved are not clear. We performed a quantitative lipidomics analysis of virus-infected cells by combining high-performance thin-layer chromatography (HPTLC) and mass spectrometry, using an established HCV cell ...
Mosleh M Abomughaid +2 more
exaly +4 more sources
Aberrant Estrogen Regulation of PEMT Results in Choline Deficiency-associated Liver Dysfunction [PDF]
Journal of Biological Chemistry, 2011 When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of premenopausal women is protected from CDS. Because hepatic PEMT (phosphatidylethanolamine N-methyltransferase) catalyzes de novo biosynthesis of choline ...
Steven H Zeisel
exaly +3 more sources
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A study of the PEMT gene in schizophrenia
Neuroscience Letters, 2007The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2.
Jieping Shi, Jun Wei
exaly +3 more sources
Choline Deficiency–Induced Liver Damage Is Reversible in Pemt−/− Mice
Journal of Nutrition, 2002Hepatic tissue has two pathways for phosphatidylcholine (PC) synthesis, i.e., the cytidinediphosphocholine (CDP-choline) pathway and the methylation pathway, which utilizes phosphatidylethanolamine-N-methyltransferase (PEMT). Fatal liver damage occurs in Pemt(-/-)mice fed a choline-deficient (CD) diet.
Dennis E Vance, Rabih Abou Farraj
exaly +3 more sources
Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance
FASEB Journal, 2019ABSTRACT Phosphatidylethanolamine (PE) N ‐methyltransferase (PEMT) accounts for ∼30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt −/− mice fed a high‐fat diet ...
Dennis E Vance +2 more
exaly +3 more sources
Polymer, 1992
Abstract An i.r. study has been made of the conformational transitions which accompany the tensile drawing of poly(ethylene terephthalate) (PET) and the non-crystallizing polyesters, poly(ethylene methyl terephthalate) (PEMT) and a 60 40 PEMT/PET copolymer.
P SPIBY, M ONEILL, R DUCKETT, I WARD
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Abstract An i.r. study has been made of the conformational transitions which accompany the tensile drawing of poly(ethylene terephthalate) (PET) and the non-crystallizing polyesters, poly(ethylene methyl terephthalate) (PEMT) and a 60 40 PEMT/PET copolymer.
P SPIBY, M ONEILL, R DUCKETT, I WARD
exaly +2 more sources
PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile
Epigenomics, 2022Aim: To assess the association between PEMT variants and nonsyndromic cleft lip with or without cleft palate in Chile and the effects of these variants on global DNA methylation. Subjects & methods: The authors obtained genotypes for nine variants from 247 cases and 453 controls for genotype-phenotype associations.
José Suazo +6 more
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Association between PEMT rs7946 and blood pressure levels in Chinese adolescents
Blood Pressure MonitoringObjectives This study was to explore blood pressure levels in Chinese adolescents with different genotypes of phosphatidylethanolamine N-methyltransferase (PEMT) gene (PEMT) rs7946, as well as effects of dietary intake on blood pressure levels with different genders and different genotypes of PEMT rs7946.
Guo Ming, Su +6 more
openaire +2 more sources
European Journal of Nutrition, 2020
Cystic Fibrosis (CF) is an autosomal recessive disorder with life-threatening organ manifestations. 87% of CF patients develop exocrine pancreas insufficiency, frequently starting in utero and requiring lifelong pancreatic enzyme substitution. 99% develop progressive lung disease, and 20-60% CF-related liver disease, from mild steatosis to cirrhosis ...
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Cystic Fibrosis (CF) is an autosomal recessive disorder with life-threatening organ manifestations. 87% of CF patients develop exocrine pancreas insufficiency, frequently starting in utero and requiring lifelong pancreatic enzyme substitution. 99% develop progressive lung disease, and 20-60% CF-related liver disease, from mild steatosis to cirrhosis ...
openaire +2 more sources