Results 81 to 90 of about 5,901 (191)

Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo[S]

Journal of Lipid Research, 2011
Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the ...
Christopher J. Pynn, Neil G. Henderson, Howard Clark, Grielof Koster, Wolfgang Bernhard, Anthony D. Postle   +5 more
doaj   +1 more source

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. [PDF]

, 2011
The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein ...
AK Cardozo, Alexander R. Ivanov, B Cox, D Ron, E Erbay, G Li, GS Hotamisligil, Gökhan S. Hotamisligil, H Cao, HF Lodish, HL Kammoun, J Schiller, KH Cheng, L Moore, Lee Dicker, Ling Yang, M Kars, MF Gregor, MS Brown, NM Borradaile, Oliver Hofmann, Ping Li, RL Jacobs, S Oyadomari, SJ Kim, Steven M. Watkins, Suneng Fu, SW Park, SY Li, U Ozcan, Winston Hide, Xihong Lin, Y Li, Y Miyauchi   +33 more
core   +2 more sources

Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous system [PDF]

, 2014
BACKGROUND:Chlamydia trachomatis is an obligate intracellular human pathogen causing ocular and urogenital infections that are a significant clinical and public health concern.
Almeida, Filipe, Borges, Vitor, Borrego, Maria, da Cunha, Maria, Gomes, João, Mauricio, Rui, Milho, Catarina, Mota, Luis, Pais, Sara   +8 more
core   +2 more sources

Lipidomic Comparison of Detergent‐Soluble and Detergent‐Resistant Lipid Domains Isolated From Rat Cerebellum and the Effect of Hypoxia–Ischemia Using UPLC‐HDMSE

Journal of Mass Spectrometry, Volume 61, Issue 1, January 2026.
ABSTRACT Hypoxic ischemic encephalopathy (HIE) due to insufficient oxygen or blood flow to the brain can result in inflammation, impaired neurodevelopment, or death. Changes to microdomain lipid composition may contribute to altered structure and function of key regulatory processes; however, knowledge regarding changes to membrane lipid composition ...
Samuel A. Krug, Min He, Ningfeng Tang, Cynthia Bearer, Maureen A. Kane   +4 more
wiley   +1 more source

Evidence for partial epithelial‐to‐mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly [PDF]

Developmental Dynamics, 2011
AbstractEmbryonic epiboly has become an important developmental model for studying the mechanisms underlying collective movements of epithelial cells. In the last couple of decades, most studies of epiboly have utilized Xenopus or zebrafish as genetically tractable model organisms, while the avian epiboly model has received virtually no attention. Here,
Matt A, Futterman, Andrés J, García, Evan A, Zamir   +2 more
openaire   +2 more sources

Artificial intelligence for risk assessment and outcome prediction in malignant haematology

British Journal of Haematology, Volume 208, Issue 1, Page 25-38, January 2026.
Machine learning models allow for dynamic and scalable risk stratification and outcome prediction. Different modalities of data such as electronic health records, patient genetics or laboratory results can be used as input. ML models autonomously select features weighing their prognostic value. Methods of model explainability in feature selection allow
Jan‐Niklas Eckardt, Wencke Walter, Jan Moritz Middeke, Torsten Haferlach   +3 more
wiley   +1 more source

Epigenetic repression of phosphatidylethanolamineN-methyltransferase (PEMT) inBRCA1-mutated breast cancer

Oncotarget, 2014
Phosphatidylethanolamine N-methyltransferase (PEMT) plays a critical role in breast cancer progression. However, the epigenetic mechanism regulating PEMT transcription remains largely unknown. Here, we show that the first promoter-specific transcript 1 is the major PEMT mRNA species, and methylation of the -132 site is a key regulatory element for the ...
Da, Li, Fang-Fang, Bi, Na-Na, Chen, Ji-Min, Cao, Wu-Ping, Sun, Yi-Ming, Zhou, Chen, Cao, Chun-Yan, Li, Qing, Yang   +8 more
openaire   +3 more sources

Comparison of Four Space Propulsion Methods for Reducing Transfer Times of Manned Mars Mission

, 2015
We assess the possibility of reducing the travel time of a manned mission to Mars by examining four different propulsion methods, and keeping the mass at departure under 2,500 tonnes, for a fixed architecture. We evaluated representative systems of three
Bertolami, O., Gil, P. J. S., Guerra, A. G. C.   +2 more
core  

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Applying Quality by Design to Digital Twin Supported Scale‐Up in Modular Plants

Chemie Ingenieur Technik, Volume 97, Issue 11-12, Page 1127-1137, November 2025.
Modular Plants are highly flexible and scalable and thus have potential utility to support faster time‐to‐process. Digital Twins of these modules require FAIR data and prior knowledge from the different domains in process development to describe the equipment capabilities. These equipment‐based Digital Twins can be combined with methods such as Quality
Amy Koch, Isabell Viedt, Andreas Bamberg, Leon Urbas   +3 more
wiley   +1 more source