Results 61 to 70 of about 5,901 (191)

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg   +8 more
wiley   +1 more source

Usability of a Patient Education and Motivation Tool Using Heuristic Evaluation

Journal of Medical Internet Research, 2009
BackgroundComputer-mediated educational applications can provide a self-paced, interactive environment to deliver educational content to individuals about their health condition. These programs have been used to deliver health-related information about a
Joshi, Ashish, Arora, Mohit, Dai, Liwei, Price, Kathleen, Vizer, Lisa, Sears, Andrew   +5 more
doaj   +1 more source

The impact of using text-to-speech (TTS) in post-editing machine translation (PEMT) workflows on translators’ cognitive effort, productivity, quality, and perceptions

Revista Tradumàtica
This eye-tracking experiment investigates the impact of text-to-speech (TTS) alongside translation and post-editing machine translation (PEMT) experience on translators’ cognitive effort, productivity, quality, and perceptions during PEMT from English ...
Dragos Ciobanu, Miguel Rios, Alina Secară, Justus Brockmann, Raluca-Maria Chereji, Claudia Wiesinger   +5 more
doaj   +1 more source

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring [PDF]

, 2017
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment.
Bahous, RH, Bedell, BJ, Caudill, MA, Cosin-Tomas, M, Deng, L, Greene, NDE, Ho, M-K, Jadavji, NM, Kaliman, P, Leung, K-Y, Lu, J, Malysheva, O, Pallas, M, Rozen, R   +13 more
core   +1 more source

Improved red blood cell storage quality of blood from donors carrying the hypermorphic PIMT I120 variant

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Protein‐l‐isoaspartate O‐methyltransferase (PIMT), encoded by PCMT1, is a repair enzyme that corrects isoaspartyl lesions, preserving protein structure and function. While indispensable for neuronal integrity, its role in red blood cells (RBCs) and transfusion outcomes is incompletely understood.
Shaun Bevers, Aaron V. Issaian, Ariel Hay, Gregory R. Keele, Monika Dzieciatkowska, Julie A. Reisz, Zachary B. Haiman, Travis Nemkov, Daniel Stephenson, Amy L. Moore, Xutao Deng, Mars Stone, Kirk C. Hansen, Steve Kleinman, Philip J. Norris, Michael P. Busch, Bernhard O. Palsson, Nareg H. Roubinian, John Janetzko, Beat Vӧgeli, Grier P. Page, David N. Jones, Morkos A. Henen, Elan Z. Eisenmesser, James C. Zimring, Angelo D'Alessandro   +25 more
wiley   +1 more source

LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk [PDF]

, 2014
BACKGROUND: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation level and bladder cancer risk
Amaral, A. F. S, Carrato, A, Chanock, S, Fernandez, A. F, Fraga, M. F, Garcia-Closas, M, Garcia-Closas, R, Jackson, B. P, Kogevinas, M, Malats, N, Marquez, M, Real, F. X, Rothman, N, Silverman, D. T, Spanish Bladder Canc, Epicuro Study, Tajuddin, S. M, Tardon, A, Torano, E. G, Urdinguio, R. G   +18 more
core   +3 more sources

Phosphorus Acquisition Strategies Among Phytoplankton and Free‐Living Bacterial Communities in the Baltic Proper

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Phosphorus is a key element for cellular functions and poses significant challenges for planktonic microbial communities under limited availability. Metagenomics highlighted that heterotrophic bacteria predominantly relied on phosphate scavenging while eukaryotic phytoplankton primarily utilized membrane remodelling to cope with limited phosphorus ...
Mollica Thomas, Farnelid Hanna, Lindehoff Elin, Lundin Daniel, Pinhassi Jarone, Legrand Catherine   +5 more
wiley   +1 more source

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

Pregnancy increases the use of choline derived methyl groups for phosphatidylcholine (PC) production through the PEMT pathway with subsequent selective transfer of PEMT‐PC to the fetus

The FASEB Journal, 2013
To quantify the effect of pregnancy on the metabolic use of orally consumed choline, healthy pregnant (P, n = 26, wk 27 gestation) and nonpregnant (NP, n = 21) women consumed ~22% of their total choline intake (480 or 930 mg/d) as ...
Jian Yan, Allyson A West, Xinyin Jiang, Cydne A Perry, Olga V Malysheva, Marie A Caudill   +5 more
openaire   +1 more source

Post-Editing Machine Translation (PEMT) as the preference method for university students in Indonesia

ELT Forum: Journal of English Language Teaching, 2023
Language translating process by Indonesian students is particularly suffered from many errors. Its defined strategy should be carefully watched due to completing its translating perfection. Thus, this study identifies the problematic translation ways commonly referred and used by university students in Indonesia.
Sitthipon Art-in, Yudistira Bagus Pratama, Haiyudi Haiyudi   +2 more
openaire   +1 more source