Results 181 to 190 of about 3,909 (203)

Regulation of renal pendrin activity by aldosterone

Current Opinion in Nephrology & Hypertension, 2021
Purpose of review Pendrin resides on the luminal membrane of type B intercalated cells in the renal collecting tubule system mediating the absorption of chloride in exchange for bicarbonate. In mice or humans lacking pendrin, blood pressure is lower, and pendrin knockout mice are resistant to aldosterone-induced hypertension ...
Bourgeois, Soline, Wagner, Carsten A
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Pendrin: linking acid base to blood pressure

Pflügers Archiv - European Journal of Physiology, 2023
Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which is mutated in human patients affected by Pendred syndrome, an autosomal recessive disease characterized by sensoneurinal deafness and hypothyroidism. Pendrin is also expressed in the kidney where it mediates the exchange of internal HCO3- for external Cl- at the apical ...
Brazier, François, Cornière, Nicolas, Picard, Nicolas, Chambrey, Régine, Eladari, Dominique   +4 more
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Localization of pendrin in mouse kidney

American Journal of Physiology-Renal Physiology, 2003
Pendrin is an anion exchanger expressed in type B intercalated cells of the cortical collecting duct (CCD). Whether pendrin localizes to other nephron segments with intercalated cells is unknown. Moreover, whether pendrin is expressed in proximal tubule is debated.
Susan M, Wall, Kathryn A, Hassell, Ines E, Royaux, Eric D, Green, Judy Y, Chang, Gregory L, Shipley, Jill W, Verlander   +6 more
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The role of pendrin in iodide regulation

Experimental and Clinical Endocrinology & Diabetes, 2001
Recent advances in human genetics have catalyzed the attention on Pendred's syndrome and its disease-gene, PDS. Studies on the expression of the PDS gene and on the function of its encoded protein, which has been named pendrin, are currently in progress.
L. Fugazzola, N. Cerutti, D. Mannavola, G. Vannucchi, P. Beck-Peccoz   +4 more
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The Role of Pendrin in Renal Physiology

Annual Review of Physiology, 2015
Pendrin is a Na+-independent Cl−/HCO3− exchanger that localizes to type B and non-A, non-B intercalated cells, which are expressed within the aldosterone-sensitive region of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the cortical collecting duct. Type B cells mediate Cl− absorption and HCO3− secretion primarily through
Susan M, Wall, Yoskaly, Lazo-Fernandez
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The Pendrin Polypeptide

2017
Pendrin (SLC26A4) is an electroneutral anion exchanger in which function-altering mutations cause inherited forms of non-syndromic (DFNB4) and syndromic deafness (Pendred syndrome) characterized by inner ear malformations. Elevated pendrin expression has also been identified as a risk modifier for inflammatory and infectious lung diseases. In addition,
Silvia Dossena, Emanuele Bernardinelli, Alok K. Sharma, Seth L. Alper, Markus Paulmichl   +4 more
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Functional cross talk between ENaC and pendrin

American Journal of Physiology-Renal Physiology, 2007
EPITHELIAL Na CHANNELS (ENaC) are expressed in the aldosterone-sensitive distal nephron, where they serve as the final site of renal Na reabsorption and participate in the regulation of extracellular fluid volume and blood pressure. ENaC gain-offunction mutations are associated with hypertension, whereas loss-of-function mutations are associated with ...
Rebecca P, Hughey, Thomas R, Kleyman
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PENDRIN PROTEIN PRESENT IN EURYHALINE ELASMOBRANCH!

Journal of Experimental Biology, 2003
![Figure][1] Pendrin is a recently discovered protein in mammals that has the ability to transport chloride ions in exchange for a variety of different molecules including bicarbonate. Chloride/bicarbonate exchange is important in euryhaline organisms and it insures chloride uptake when ...
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