Results 71 to 80 of about 601,393 (323)

WENO schemes applied to the quasi-relativistic Vlasov--Maxwell model for laser-plasma interaction [PDF]

, 2014
In this paper we focus on WENO-based methods for the simulation of the 1D Quasi-Relativistic Vlasov--Maxwell (QRVM) model used to describe how a laser wave interacts with and heats a plasma by penetrating into it.
Labrunie, Simon, Mulet, Pep, Vecil, Francesco   +2 more
core   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Fire extinguishing apparatus having a slidable mass for a penetrator nozzle [PDF]

, 1980
A fire extinguishing apparatus for delivering an extinguishing agent through a tarrier surrounding a structure into its interior includes an elongated tubular nozzle body which has a pointed penetrating head carried on one end of the tubular body.
Bolton, P. N., Gray, N. C., Senseny, R. M.   +2 more
core   +1 more source

Cell-Penetrating Peptides, Electroporation, and Drug Delivery

, 2010
Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis.
Cahill, Kevin
core   +1 more source

WSES classification and guidelines for liver trauma [PDF]

, 2016
The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries ...
Abu-Zidan, Fikri M., Ansaloni, Luca, Biffl, Walter, Catena, Fausto, Ceresoli, Marco, Coccolini, Federico, Coimbra, Raul, Fraga, Gustavo, Ivatury, Rao, Kluger, Yoram, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Peitzman, Andrew, Rizoli, Sandro, Sartelli, Massimo, Weber, Dieter, Zanini, Nicola   +18 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Injury to the Temporal Lobe via Medial Transorbital Entry of a Toothbrush

Journal of Neurological Surgery Reports, 2013
Objectives Intracranial penetration by foreign bodies entering via the orbit represent an unusual form of traumatic brain injury. Nevertheless, much is at stake with high risk for cranial nerve and neurovascular injury.
Jesse Skoch, Tracy L. Ansay, G. M. Lemole   +2 more
doaj   +1 more source

Penetrating Abdominal Injury by a Large Stone [PDF]

, 2012
Penetrating trauma can be commonly caused by sharp objects. We report a case of penetrating injury of abdomen caused by a fairly large sized stone which is used for sharpening the objects or weapons.
Baitha, K, Kamble, AT, Kaple, MN, Mahakalkar, CC   +3 more
core  

p-Branes and the GZK Paradox

, 2002
In spacetimes with asymmetric extra dimensions, cosmic neutrino interactions may be extraordinarily enhanced by p-brane production. Brane formation and decay may then initiate showers deep in the Earth's atmosphere at rates far above the standard model ...
Ahn, Alvarez-Muniz, Anchordoqui, Anchordoqui, Anchordoqui, Antoniadis, Argyres, Arkani-Hamed, Banks, Barger, Cavaglià, Cullen, Dimopoulos, Dimopoulos, Eardley, Emparan, Emparan, Feng, Giddings, Giddings, Giddings, Giddings, Goldberg, Gregory, Greisen, Haim Goldberg, Hall, Hanhart, Hannestad, Hannestad, Hoyle, Jain, Jonathan L. Feng, Kowalski, Lai, Lee, Luis A. Anchordoqui, Lykken, Lykken, Myers, Protheroe, Protheroe, Randall, Ringwald, Sen, Sen, Shiu, Solodukhin, Tyler, Voloshin, Voloshin, Yoshida, Zatsepin   +52 more
core   +1 more source