Results 101 to 110 of about 391,647 (282)

A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation [PDF]

, 2014
During early development, modulations in the expression of Nodal, a TGFβ family member, determine the specification of embryonic and extra-embryonic cell identities.
Jérôme Collignon (34631), Francina Langa (49327), Jérôme Collignon, Ataaillah Benhaddou (588226), Ataaillah Benhaddou, Costis Papanayotou, Valérie Mezger (588227), Délara Sabéran-Djoneidi (588228), Collignon, Jérôme, Aitana Perea-Gomez, Délara Sabéran-Djoneidi, Aitana Perea-Gomez (34627), Anne Camus (246751), Perea-Gomez, Aitana, Jouneau, Alice, Camus, Anne, Langa, Francina, Benhaddou, Ataaillah, Francina Langa, Sascha Ott, Anne Camus, Sabéran-Djoneidi, Délara, Alice Jouneau, Papanayotou, Costis, Costis Papanayotou (83558), Sascha Ott (192042), Alice Jouneau (328085), Ott, Sascha, Mezger, Valérie, Valérie Mezger, Ott Sascha, Perea-Gomez Aitana, Collignon Jérôme, Langa Francina, Mezger Valérie, Sabéran-Djoneidi Délara, Benhaddou Ataaillah, Camus Anne, Papanayotou Costis, Jouneau Alice   +39 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer. [PDF]

Sci Rep, 2021
Bayoumi M, Arafa MG, Nasr M, Sammour OA.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Effect of Glycerin as Penetration Enhancer in a Ketoprofen Solid Preparation–Patch on In Vitro Penetration Study through Rat Skin

, 2020
Context: The side effect of Ketoprofen in oral administration is gastrointestinal disorders and kidney failure. The transdermal route can solve this problem, and need penetration enhancer to increase the penetration into the skin.
NURAHMANTO, Dwi, AMELIANA, Lidya, PRATAMA, Ferina Nadya, UMAM, Choirul   +3 more
core  

Further Evaluation of a New Penetration Enhancer, HPE-101

, 1993
The penetration enhancer, 1-[2-(decylthio)ethyl]azacyclopentan-2-one (HPE-101), significantly enhanced the excretion of topically applied [14C]indomethacin when dissolved in dipropylene glycol, triethylene glycol, diethylene glycol, 1,3-butylene glycol ...
Kazuya Fukuda, Tadanori Yano, Naruhito Higo, Masayoshi Tsuji, Masaki Otagiri, Kanji Noda   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Water-filtered infrared-A (wIRA) can act as a penetration enhancer for topically applied substances

GMS German Medical Science, 2008
Background: Water-filtered infrared-A (wIRA) irradiation has been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by ...
Sterry, Wolfram, Ackermann, Hanns, Hoffmann, Gerd, Schanzer, Sabine, Meyer, Lars, Grone, Diego, Otberg, Nina, Lademann, Jürgen   +7 more
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source