Results 111 to 120 of about 391,647 (282)

Penetration of fastener projectiles into construction materials [PDF]

, 1988
The normal impact, penetration of both projectile and fastener into soils, rocks, and concrete at low velocities has been investigated using theoretical, experimental, and numerical approaches under axisymmetric conditions.
Zhou, Gang
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycodeoxycholate

, 1998
For many drugs, buccal route offers many advantages over conventional routes of delivery with an improved bioavailability due to the avoidance of degradation in the gastrointestinal tract and hepatic first-pass metabolism.
Hincal, AA, Senel, SEVDA, Capan, YILMAZ, Sargon, MUSTAFA FEVZİ, Giray, CELAL BAHADIR   +4 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Effect of Penetration Enhancer DMSO on In-Vitro Skin Permeation of Acyclovir Transdermal Microemulsion Formulation [PDF]

, 2011
The aim of this research was to enhance the flux of transdermal drug delivery by using penetration enhancers DMSO. Skin penetration enhancers have been used to improve bioavailability and increase the range of drugs for which topical and transdermal ...
Jain, S. K.; Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.) -284128, India, Prajapati, S.K.; Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.) -284128, India, Kumar, Brajesh; Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.) -284128, India   +2 more
core   +2 more sources

Enhancer-Gene Interaction Analyses Identified EGFR as a Susceptibility Gene for Type 2 Diabetes Supplementary Files

, 2019
Supplementary Files for the paper entitled "Enhancer-Gene Interaction Analyses Identified EGFR as a Susceptibility Gene for Type 2 Diabetes"
Shi Yao (6938408)
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

EVALUATION OF MYRISTICA FRAGRANS AS A PENETRATION ENHANCER IN TRANSDERMAL GEL FORMULATION [PDF]

, 2015
Objective: Skin delivery of NSAIDs offers several advantages over oral route associated with potential side effects. The study aims at exploring the potential of Myristica fragrans as a penetration enhancer (PE) for transdermal gel of Diclofenac sodium ...
Bhide, Manali A., Patwardhan, Sunetra K.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source