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Current Drug Targets, 2015 The aim of this study was to elucidate the influence of the edge activator structure on the properties of novel deformable liposomes, Penetration Enhancer-containing Vesicles (PEVs), capable of delivering drugs to the skin.
Chiara Sinico +2 more
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Advanced Drug Delivery Reviews, 2004
One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) which penetrate into skin to reversibly decrease the barrier resistance. Numerous compounds have been evaluated for penetration enhancing activity, including sulphoxides (such as dimethylsulphoxide, DMSO), Azones
Adrian C Williams, Brian W. Barry
exaly +3 more sources
One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) which penetrate into skin to reversibly decrease the barrier resistance. Numerous compounds have been evaluated for penetration enhancing activity, including sulphoxides (such as dimethylsulphoxide, DMSO), Azones
Adrian C Williams, Brian W. Barry
exaly +3 more sources
Penetration Enhancers in Ocular Drug Delivery [PDF]
Pharmaceutics, 2019 There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes.
Peter W J Morrison +2 more
exaly +5 more sources
Chemical Penetration Enhancers
Therapeutic Delivery, 2015To achieve an efficient skin penetration of most compounds it is necessary to overcome the barrier function of the skin, provided mainly (but not only) by the stratum corneum. Among various strategies used or studied to date, chemical penetration enhancers are the most frequently employed with one of the longest histories of use.
Luciana B, Lopes +2 more
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Percutaneous Penetration Enhancers: An Overview
Skin Pharmacology and Physiology, 2007Transdermal drug delivery is the controlled release of drugs through the skin to obtain therapeutic levels systematically. Several technological advances have been made in the recent decades to enhance percutaneous drug penetration. This overview focuses on the physical, biochemical, and chemical means of penetration enhancement, as well as the ...
H-Y, Thong, H, Zhai, H I, Maibach
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Penetration Enhancers Assessed by Corneoxenometry
Skin Pharmacology and Physiology, 2000Chemical enhancers abating the barrier function of the stratum corneum act in a number of ways. Their relative effects in mixtures are notoriously difficult to determine. Corneoxenometry is a bioassay where xenobiotic interactions with corneocytes are assessed using reflectance colorimetry.
V, Goffin +3 more
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Mucosal Penetration Enhancement
Journal of Drug Targeting, 1995(1995). Mucosal Penetration Enhancement. Journal of Drug Targeting: Vol. 3, No. 3, pp. 175-177.
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Enhancement of Ocular Drug Penetration
Critical Reviews in Therapeutic Drug Carrier Systems, 1999Although new drugs have recently been developed within the field of ophthalmology, the eye's various defense mechanisms make it difficult to achieve an effective concentration of these drugs within the eye. Drugs administered systemically have poor access to the inside of the eye because of the blood-aqueous and blood-retinal barriers.
H, Sasaki +6 more
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International Journal of Pharmaceutics, 2013
The skin has evolved to prevent excessive water loss from the internal organs and to limit the ability of xenobiotics and hazardous substances to enter the body. Notwithstanding this barrier function, a number of strategies have been developed by scientists to deliver drugs to and through the skin.
openaire +2 more sources
The skin has evolved to prevent excessive water loss from the internal organs and to limit the ability of xenobiotics and hazardous substances to enter the body. Notwithstanding this barrier function, a number of strategies have been developed by scientists to deliver drugs to and through the skin.
openaire +2 more sources
Supersaturation as a Tool For Skin Penetration Enhancement
Current Pharmaceutical Design, 2015Supersaturated systems have attracted interest to enhance the skin penetration because of the low cost and reduced risks of irritation with respect to other approaches. The mechanism is simply based on the increased drug driving force for transit out of the dosage form and penetrate the stratum corneum.
F. Cilurzo +3 more
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