Results 181 to 190 of about 460,006 (298)

Light‐Driven Quadrupedal Walking Biohybrid Robot With Antagonistic Muscle‐Rings and Inclined Joints

Advanced Robotics Research, EarlyView.
This work presents a light‐driven quadrupedal walking biohybrid robot powered by antagonistic muscle‐rings that achieve alternating walking gait. Optical training improved reproducibility of cultured muscle tissues, while caffeine treatment enhanced contractile force.
Shotaro Saito, Byeongwook Jo, Tomohiro Morita, Shota Noda, Minghao Nie, Shoji Takeuchi   +5 more
wiley   +1 more source

Identification of Antibacterial Hits Associated with Penicillin-Binding Protein 2 in <i>Escherichia coli</i> Using a Comprehensive Property Spectrum and Fivefold Maximum Drug-Likeness Strategy. [PDF]

Drug Des Devel Ther
Zhu H, Du S, Yang Q, Xu L, Shi W.
europepmc   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

Journal of Bacteriology, 1984
B. Hartman, A. Tomasz
semanticscholar   +1 more source

Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of <i>Streptococcus pneumoniae</i> Penicillin-Binding Protein 2x. [PDF]

J Med Chem
Dominguez-Cisneros H, Konai MM, Kim C, Rana N, Feltzer R, Janardhanan J, El-Araby AM, Nguyen VT, Fisher JF, Chang M, Mobashery S.   +10 more
europepmc   +1 more source

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA). [PDF]

Molecules, 2023
Ambade SS, Gupta VK, Bhole RP, Khedekar PB, Chikhale RV.   +4 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Loss-of-Function Mutations in the Penicillin-Binding Protein PonA1 Confer Agar-Dependent Resistance to Durlobactam in <i>Mycobacterium abscessus</i>. [PDF]

Antibiotics (Basel)
Negatu DA, Aragaw WW, Xie M, Dartois V, Dick T.   +4 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Repurposing the angiotensin II receptor blocker valsartan to inhibit penicillin-binding protein 3 and its mutants in <i>Haemophilus influenzae</i>: a comprehensive <i>in silico</i> approach. [PDF]

Front Bioinform
Kacha S, Arun J, Nargund N, Joshi T, Mathpal S, Ramaiah S, Anbarasu A.   +6 more
europepmc   +1 more source