Peptidoglycan recruitment by a penicillin binding protein [PDF]
Nature CommunicationsThe cell wall is essential for bacterial survival. Its core component is peptidoglycan (PG), a polymer comprised of disaccharide-peptides (stem peptides) that are cross-linked to one another via transpeptidation by penicillin-binding proteins (PBPs ...
Yamanappa Hunashal +11 more
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Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors [PDF]
Antibiotics, 2022 Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of mecA (or mecC), which encodes an alternative penicillin binding protein, PBP2a, with low β-lactam ...
Mikaeel Young +10 more
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Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6 [PDF]
Life, 2022 Shigella sonnei remains the second most common cause of shigellosis in young children and is now increasingly dominant across developing countries. The global emergence of drug resistance has become a main burden in the treatment of S.
Mohd Zulkifli Salleh +2 more
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A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu +4 more
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Localization characteristics of cell wall synthesis protein Wag31 and penicillin binding protein C in Clavibacter michiganensis [PDF]
The Cell SurfaceCmWag31 is a member of the DivIVA family of proteins in Clavibacter michiganensis. The DivIVA family have been demonstrated to play a key role in the synthesis of cell wall peptidoglycan and cell division in most bacterial species. It has been previously
Chengxuan Yu +6 more
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Gut and Liver, 2013 Background/AimsA worldwide increase in amoxicillin resistance in Helicobacter pylori is having an adverse effect on eradication therapy. In this study, we investigated the mechanism of the amoxicillin resistance of H.
Beom Jin Kim, Jae Gyu Kim
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Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria [PDF]
Biomolecules, 2021 Novel antimicrobial strategies are urgently required because of the rising threat of multi drug resistant bacterial strains and the infections caused by them.
Stefan Freischem +7 more
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Discovery and development of penicillin-binding protein-type thioesterases as biocatalysts. [PDF]
Curr Opin BiotechnolBudimir ZL, Parkinson EI.
europepmc +2 more sources
Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryPenicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives.
Levente Kollár +7 more
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Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis [PDF]
Advances in Pharmacological and Pharmaceutical SciencesGonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence
Sinethemba Yakobi +2 more
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