Results 41 to 50 of about 637,867 (346)

Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. [PDF]

PLoS ONE, 2014
In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic
Eric Sauvage, Adeline Derouaux, Claudine Fraipont, Marine Joris, Raphaël Herman, Mathieu Rocaboy, Marie Schloesser, Jacques Dumas, Frédéric Kerff, Martine Nguyen-Distèche, Paulette Charlier   +10 more
doaj   +1 more source

Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole

Frontiers in Chemistry, 2022
Current treatment of Helicobacter pylori involves a triple therapy comprising one proton pump inhibitor and two other antibiotics; however, the outcomes are limited due to the existence of antibiotic resistant strains.
Yen-Yu Tseng, Jyh-Ming Liou, Wei-Chieh Cheng, Jing-Ting Hsu, Tsui-Ling Hsu, Ming-Shiang Wu, Chi-Huey Wong, Chi-Huey Wong   +7 more
doaj   +1 more source

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Gidijala, Loknath,, Kiel, Jan A.K.W.,, Klei, Ida J. van der,, Veenhuis, Marten,   +3 more
core   +2 more sources

Penicillin-binding proteins in Actinobacteria [PDF]

The Journal of Antibiotics, 2014
Because some Actinobacteria, especially Streptomyces species, are β-lactam-producing bacteria, they have to have some self-resistant mechanism. The β-lactam biosynthetic gene clusters include genes for β-lactamases and penicillin-binding proteins (PBPs), suggesting that these are involved in self-resistance. However, direct evidence for the involvement
openaire   +2 more sources

Penicillin‐Binding Protein Imaging Probes [PDF]

Current Protocols in Chemical Biology, 2013
ABSTRACTPenicillin‐binding proteins (PBPs) are membrane‐associated proteins involved in the biosynthesis of peptidoglycan (PG), the main component of bacterial cell walls. These proteins were discovered and named for their affinity to bind the β‐lactam antibiotic penicillin.
Ozden, Kocaoglu, Erin E, Carlson
openaire   +2 more sources

Allosteric p97 inhibitors can overcome resistance to ATP-competitive p97 inhibitors for potential anti-cancer therapy [PDF]

, 2020
A major challenge of targeted cancer therapy is the selection for drug‐resistant mutations in tumor cells leading to loss of treatment effectiveness. p97/VCP is a central regulator of protein homeostasis and a promising anti‐cancer target because of its ...
Chou, Tsui-Fen, Flint, Andrew J., Gan, Taiping, Li, Shan, Stott, Gordon M., Wang, Feng   +5 more
core   +1 more source

Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia

Electronic Journal of Biotechnology, 2016
Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied.
Liang-Mei Li, Jun Li, Xiu-Ying Zhang
doaj   +1 more source

Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex [PDF]

, 2013
Background: MurE controls stereo chemical incorporation of Lysine or diaminopimelate into peptidoglycan stem peptides Results: The structure of S.aureus MurE reveals an unexpected lack of specificity for Lysine within the active site.
Barreteau, Basavannacharya, Basavannacharya, Battye, Bertrand, Bertrand, Boniface, Boniface, Bouhss, Brünger, Bugg, Bugg, Chen, Clancy, Clarke, Clarke, Collaborative Computational Project, Number 4, Cox, Cressina, Crouvoisier, Cruickshank, De Lencastre, DeLano, Emsley, Ernst, Ernst, Favini-Stabile, Figueiredo, Gardete, Girardin, Gordon, Gorrec, Huber, Hutton, Jones, Kabsch, Lee, Liebeke, Lloyd, Lloyd, Lundqvist, Lysenko, Matteï, McCoy, Mei, Mengin-Lecreulx, Mengin-Lecreulx, Mohammadi, Murshudov, Münch, Ornelas-Soares, Painter, Paradis-Bleau, Paradis-Bleau, Patin, Perdih, Ray, Read, Royet, Sauvage, Scheffers, Schneider, Schouten, Smith, Sosič, Sova, Thedieck, Vagin, Vollmer, Vollmer, Walker, Young, Zawadzke   +72 more
core   +2 more sources

Affinity of cefoperazone for penicillin-binding proteins [PDF]

Antimicrobial Agents and Chemotherapy, 1980
Cefoperazone (T-1551, CFP) a new semisynthetic cephalosporin, has a broad spectrum of antibacterial activity. We investigated the affinity of CFP to penicillin-binding proteins (PBPs) and the inhibition of peptidoglycan synthesis by CFP. CFP had high affinities for Escherichia coli PBP-3, -1Bs, -2, and -1A, in descending order, and low affinities for ...
N, Matsubara, S, Minami, M, Matsuhashi, M, Takaoka, S, Mitsuhashi   +4 more
openaire   +2 more sources

Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams

Nature Communications, 2022
β-lactam-induced bacterial killing is complex and not fully resolved. Authors carry out a genome-wide analysis, through penicillin-binding protein replacement, to identify genes essential for drug efficacy.
Henri Voedts, Sean P. Kennedy, Guennadi Sezonov, Michel Arthur, Jean-Emmanuel Hugonnet   +4 more
doaj   +1 more source