Results 21 to 30 of about 637,867 (346)

Novel Penicillin Analogues as Potential Antimicrobial Agents; Design, Synthesis and Docking Studies. [PDF]

PLoS ONE, 2015
A number of penicillin derivatives (4a-h) were synthesized by the condensation of 6-amino penicillinic acid (6-APA) with non-steroidal anti-inflammatory drugs as antimicrobial agents.
Zaman Ashraf, Abdul Bais, Md Maniruzzaman Manir, Umar Niazi   +3 more
doaj   +1 more source

Construction and Activity Testing of a Modular Fusion Peptide against Enterococcus faecalis

Antibiotics, 2023
The emergence of antibiotic resistance in enterococci is a great concern encountered worldwide. Almost all enterococci exhibit significant levels of resistance to penicillin, ampicillin, semi-synthetic penicillin and most cephalosporins, primarily due to
Salim Manoharadas, Mohammad Altaf, Naushad Ahmad, Abdulwahed Fahad Alrefaei, Basel F. Al-Rayes   +4 more
doaj   +1 more source

Molecular docking of human serum albumin with penicillin G determinants

Біофізичний вісник, 2023
Background: Human serum albumin (HSA) is the main pharmacokinetic effector of many medications, including penicillin G and its metabolites. An urgent problem of practical medicine is immediate hypersensitivity reactions caused by penicillin toxicity ...
N. V. Khmil, V. G. Kolesnikov
doaj   +1 more source

Molecular Characterization of Penicillin-Binding Protein2x, 2b and 1a of Streptococcus pneumoniae Causing Invasive Pneumococcal Diseases in China: A Multicenter Study

Frontiers in Microbiology, 2022
Streptococcus pneumoniae is a common human pathogen that can cause severe invasive pneumococcal diseases (IPDs). Penicillin-binding proteins (PBPs) are the targets for β-lactam antibiotics (BLAs), which are the common empirical drugs for treatment of ...
Menglan Zhou, Menglan Zhou, Lulu Wang, Ziran Wang, Ziran Wang, Timothy Kudinha, Timothy Kudinha, Yao Wang, Yao Wang, Yingchun Xu, Yingchun Xu, Zhengyin Liu   +11 more
doaj   +1 more source

Identification and Crystallization of Penicillin-Binding Protein/β-Lactamase Homolog (Rp46) from Ruegeria Pomeroyi

Crystals, 2016
In spite of the enormous biological and clinical significance of penicillin-binding protein (PBP)/β-lactamase (βL), few of their many homologs (PBP)/βLs homologs) have been studied crystallographically, and have known functions.
Bum Han Ryu, Tri Duc Ngo, Wanki Yoo, Kyeong Kyu Kim, T. Doohun Kim   +4 more
doaj   +1 more source

On Column Binding a Real-Time Biosensor for β-lactam Antibiotics Quantification

Molecules, 2020
This work aimed to develop accurate, quick, and practical tools for the detection of residues of penicillin G antibiotic in biological and non-biological samples.
Shahla M. Abdullah, Shwan Rachid
doaj   +1 more source

Facilitation of penicillin haptenation to serum proteins. [PDF]

, 1993
Traditionally, penicillin binding to serum proteins was believed to be a passive chemical process; however, it appears to be facilitated by serum factors.
Adkinson, N. Franklin, Jr., DiPiro, Joseph T., Hamilton, Robert G.   +2 more
core   +3 more sources

Penicillin-Binding Proteins in Leptospira interrogans [PDF]

Antimicrobial Agents and Chemotherapy, 2001
ABSTRACT The Leptospira interrogans ponA and pbpB genes were isolated and characterized. ponA and pbpB encode the penicillin-binding proteins (PBPs) 1 and 3, respectively.
Brenot, A, Trott, D. J., Saint Girons, I., Zuerner, R.L.   +3 more
openaire   +6 more sources

The penicillin binding protein 1A of Helicobacter pylori, its amoxicillin binding site and access routes

Gut Pathogens, 2021
Background Amoxicillin-resistant H. pylori strains are increasing worldwide. To explore the potential resistance mechanisms involved, the 3D structure modeling and access tunnel prediction for penicillin-binding proteins (PBP1A) was performed, based on ...
Bahareh Attaran, Najmeh Salehi, Bahareh Ghadiri, Maryam Esmaeili, Shadi Kalateh, Mohammad Tashakoripour, Mahmoud Eshagh Hosseini, Marjan Mohammadi   +7 more
doaj   +1 more source

Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4.

PLoS ONE, 2011
Neisseria meningitidis is a human pathogen responsible for life-threatening inflammatory diseases. Meningococcal penicillin-binding proteins (PBPs) and particularly PBP2 are involved in bacterial resistance to β-lactams. Here we describe a novel function
Marcelo Hill, Ala-Eddine Deghmane, Mercedes Segovia, Maria Leticia Zarantonelli, Gaëlle Tilly, Philippe Blancou, Gaëlle Bériou, Régis Josien, Ignacio Anegon, Eva Hong, Corinne Ruckly, Aude Antignac, Meriem El Ghachi, Ivo Gomperts Boneca, Muhamed-Kheir Taha, Maria Cristina Cuturi   +15 more
doaj   +1 more source