Results 1 to 10 of about 635,610 (300)

Peptidoglycan recruitment by a penicillin binding protein [PDF]

Nature Communications
The cell wall is essential for bacterial survival. Its core component is peptidoglycan (PG), a polymer comprised of disaccharide-peptides (stem peptides) that are cross-linked to one another via transpeptidation by penicillin-binding proteins (PBPs ...
Yamanappa Hunashal, Matthieu Fonvielle, Masumi Takayama Kobayashi, Meng S. Choy, Ganesan Senthil Kumar, Paul Ugalde Silva, Yucheng Liang, Charlene Desbonnet, Louis B. Rice, Michel Arthur, Rebecca Page, Wolfgang Peti   +11 more
doaj   +4 more sources

Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors [PDF]

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of mecA (or mecC), which encodes an alternative penicillin binding protein, PBP2a, with low β-lactam ...
Mikaeel Young, Danica J. Walsh, Elysia Masters, Vijay Singh Gondil, Emily Laskey, Michael Klaczko, Hani Awad, James McGrath, Edward M. Schwarz, Christian Melander, Paul M. Dunman   +10 more
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Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6 [PDF]

Life, 2022
Shigella sonnei remains the second most common cause of shigellosis in young children and is now increasingly dominant across developing countries. The global emergence of drug resistance has become a main burden in the treatment of S.
Mohd Zulkifli Salleh, Kirnpal Kaur Banga Singh, Zakuan Zainy Deris   +2 more
doaj   +2 more sources

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +2 more sources

Localization characteristics of cell wall synthesis protein Wag31 and penicillin binding protein C in Clavibacter michiganensis [PDF]

The Cell Surface
CmWag31 is a member of the DivIVA family of proteins in Clavibacter michiganensis. The DivIVA family have been demonstrated to play a key role in the synthesis of cell wall peptidoglycan and cell division in most bacterial species. It has been previously
Chengxuan Yu, Xiaoli Xu, Jia Shi, Wenqing Chu, Na Jiang, Jianqiang Li, Laixin Luo   +6 more
doaj   +2 more sources

Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Penicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives.
Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű   +7 more
doaj   +2 more sources

Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis [PDF]

Advances in Pharmacological and Pharmaceutical Sciences
Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence
Sinethemba Yakobi, Lindiwe Zuma, Ofentse Pooe   +2 more
doaj   +2 more sources

Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori [PDF]

mSphere
The growing resistance to amoxicillin (AMX)—one of the main antibiotics used in Helicobacter pylori eradication therapy—is an increasing health concern.
Alain Cimuanga-Mukanya, Evariste Tshibangu-Kabamba, Patrick de Jesus Ngoma Kisoko, Kartika Afrida Fauzia, Fabien Mbaya Tshibangu, Antoine Tshimpi Wola, Pascal Tshiamala Kashala, Dieudonné Mumba Ngoyi, Steve Ahuka-Mundeke, Gunturu Revathi, Ghislain Disashi-Tumba, Yasutoshi Kido, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka   +14 more
doaj   +2 more sources

Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands

The Cell Surface, 2021
Bacteria encase their cytoplasmic membrane with peptidoglycan (PG) to maintain the shape of the cell and protect it from bursting. The enlargement of the PG layer is facilitated by the coordinated activities of PG synthesising and -cleaving enzymes.
Jad Sassine, Manuel Pazos, Eefjan Breukink, Waldemar Vollmer   +3 more
doaj   +1 more source

Repurposing Amphotericin B: anti-microbial, molecular docking and molecular dynamics simulation studies suggest inhibition potential of Amphotericin B against MRSA

BMC Chemistry, 2023
Amphotericin B (AMPH) is an anti-fungal drug and this study, for the first time as best of our knowledge, reports the repurposing of the Amphotericin B.
Neha Farid, Khair Bux, Kashif Ali, Asma Bashir, Rahima Tahir   +4 more
doaj   +1 more source