Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus [PDF]
Biochemical Journal, 1994 Reduced affinity of penicillin-binding proteins (PBPs) for binding penicillin has been proposed as a mechanism of beta-lactam antibiotic resistance in staphylococci. Penicillin binding by PBPs of three penicillin-susceptible and two penicillin-resistant strains of Staphylococcus aureus was studied in kinetic assays to determine rate constants, drug ...
H F, Chambers +2 more
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Penicillin-binding proteins of bdellovibrios [PDF]
Journal of Bacteriology, 1988 We examined the predacious gram-negative bacterium Bdellovibrio bacteriovorous 109J and free-living strains 109J-A1 and 109J-KA1 derived therefrom for penicillin-binding proteins (PBPs). We compared their PBPs with those of the host bacterium, Escherichia coli, and with those of a facultatively predacious bdellovibrio, B. stolpii UKi2, grown axenically.
J T, Park, S, Mahadevan
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Penicillin-binding proteins in bacteria [PDF]
Antimicrobial Agents and Chemotherapy, 1980 The penicilllin-binding proteins (PBPs) of several gram-positive and gram-negative bacteria have been examined. The results indicate that: (i) PBPs are membrane proteins with molecular weights ranging from 40,000 to 120,000. When extracted with Triton X-100 from sonicated cells, they appear to fall into two patterns: one found in rods and the other in ...
N H, Georgopapadakou, F Y, Liu
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Penicillins: update for clinical practice
Revista Médica de Minas Gerais, 2023 Introduction: The discovery of penicillins is one of the milestones in the history of health care. These drugs are among the most prescribed antimicrobials in the world, with applicability even today in different diseases and infectious complications ...
Rodrigo Siqueira-Batista +5 more
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Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines [PDF]
, 2020 Monocyclic beta-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-beta-lactams, of which ...
Amoroso, Ana Maria +7 more
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Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
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Novel Penicillin Analogues as Potential Antimicrobial Agents; Design, Synthesis and Docking Studies. [PDF]
PLoS ONE, 2015 A number of penicillin derivatives (4a-h) were synthesized by the condensation of 6-amino penicillinic acid (6-APA) with non-steroidal anti-inflammatory drugs as antimicrobial agents.
Zaman Ashraf +3 more
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Construction and Activity Testing of a Modular Fusion Peptide against Enterococcus faecalis
Antibiotics, 2023 The emergence of antibiotic resistance in enterococci is a great concern encountered worldwide. Almost all enterococci exhibit significant levels of resistance to penicillin, ampicillin, semi-synthetic penicillin and most cephalosporins, primarily due to
Salim Manoharadas +4 more
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Penicillin-Binding Proteins in Leptospira interrogans [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT The Leptospira interrogans ponA and pbpB genes were isolated and characterized. ponA and pbpB encode the penicillin-binding proteins (PBPs) 1 and 3, respectively.
Brenot, A +3 more
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Molecular docking of human serum albumin with penicillin G determinants
Біофізичний вісник, 2023 Background: Human serum albumin (HSA) is the main pharmacokinetic effector of many medications, including penicillin G and its metabolites. An urgent problem of practical medicine is immediate hypersensitivity reactions caused by penicillin toxicity ...
N. V. Khmil, V. G. Kolesnikov
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