Results 11 to 20 of about 460,006 (298)

Peptidoglycan recruitment by a penicillin binding protein [PDF]

Nature Communications
The cell wall is essential for bacterial survival. Its core component is peptidoglycan (PG), a polymer comprised of disaccharide-peptides (stem peptides) that are cross-linked to one another via transpeptidation by penicillin-binding proteins (PBPs ...
Yamanappa Hunashal, Matthieu Fonvielle, Masumi Takayama Kobayashi, Meng S. Choy, Ganesan Senthil Kumar, Paul Ugalde Silva, Yucheng Liang, Charlene Desbonnet, Louis B. Rice, Michel Arthur, Rebecca Page, Wolfgang Peti   +11 more
doaj   +4 more sources

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +3 more sources

Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors [PDF]

Antibiotics, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of mecA (or mecC), which encodes an alternative penicillin binding protein, PBP2a, with low β-lactam ...
Mikaeel Young, Danica J. Walsh, Elysia Masters, Vijay Singh Gondil, Emily Laskey, Michael Klaczko, Hani Awad, James McGrath, Edward M. Schwarz, Christian Melander, Paul M. Dunman   +10 more
doaj   +2 more sources

Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. [PDF]

PLoS ONE, 2014
In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic
Eric Sauvage, Adeline Derouaux, Claudine Fraipont, Marine Joris, Raphaël Herman, Mathieu Rocaboy, Marie Schloesser, Jacques Dumas, Frédéric Kerff, Martine Nguyen-Distèche, Paulette Charlier   +10 more
doaj   +2 more sources

Penicillin‐Binding Protein Imaging Probes [PDF]

Current Protocols in Chemical Biology, 2013
ABSTRACTPenicillin‐binding proteins (PBPs) are membrane‐associated proteins involved in the biosynthesis of peptidoglycan (PG), the main component of bacterial cell walls. These proteins were discovered and named for their affinity to bind the β‐lactam antibiotic penicillin.
Ozden, Kocaoglu, Erin E, Carlson
openaire   +3 more sources

Localization characteristics of cell wall synthesis protein Wag31 and penicillin binding protein C in Clavibacter michiganensis [PDF]

The Cell Surface
CmWag31 is a member of the DivIVA family of proteins in Clavibacter michiganensis. The DivIVA family have been demonstrated to play a key role in the synthesis of cell wall peptidoglycan and cell division in most bacterial species. It has been previously
Chengxuan Yu, Xiaoli Xu, Jia Shi, Wenqing Chu, Na Jiang, Jianqiang Li, Laixin Luo   +6 more
doaj   +2 more sources

Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus faecium

mBio, 2016
The intrinsic resistance of Enterococcus faecium to ceftriaxone and cefepime (here referred to as “cephalosporins”) is reliant on the presence of class A penicillin-binding proteins (Pbps) PbpF and PonA.
Charlene Desbonnet, Amelia Tait-Kamradt, Monica Garcia-Solache, Paul Dunman, Jeffrey Coleman, Michel Arthur, Louis B. Rice   +6 more
doaj   +2 more sources

Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Penicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives.
Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű   +7 more
doaj   +2 more sources

Investigation into the Interaction between Penicillin-Resistant and Penicillin-Susceptible Gonococcal Penicillin-Binding Protein 2 and Target Phenolic Ligands through Molecular Docking Studies and Structure-Activity Relationship Analysis [PDF]

Advances in Pharmacological and Pharmaceutical Sciences
Gonococcal infections present a notable public health issue, and the major approach for treatment involves using β-lactam antibiotics that specifically target penicillin-binding protein 2 (PBP2) in Neisseria gonorrhoeae. This study examines the influence
Sinethemba Yakobi, Lindiwe Zuma, Ofentse Pooe   +2 more
doaj   +2 more sources

Penicillin-binding protein (PBP) inhibitor development: A 10-year chemical perspective. [PDF]

Exp Biol Med (Maywood), 2023
Bacterial cell wall formation is essential for cellular survival and morphogenesis. The peptidoglycan (PG), a heteropolymer that surrounds the bacterial membrane, is a key component of the cell wall, and its multistep biosynthetic process is an ...
Bertonha AF, Silva CCL, Shirakawa KT, Trindade DM, Dessen A.   +4 more
europepmc   +2 more sources