Results 21 to 30 of about 460,006 (298)
Synergistic effects of novel penicillin-binding protein 1A amino acid substitutions contribute to high-level amoxicillin resistance of Helicobacter pylori [PDF]
mSphereThe growing resistance to amoxicillin (AMX)—one of the main antibiotics used in Helicobacter pylori eradication therapy—is an increasing health concern.
Alain Cimuanga-Mukanya +14 more
doaj +2 more sources
bioRxiv, 2021 While the structure and function of the bacterial cell wall are well conserved, the mechanisms responsible for cell wall biosynthesis during elongation are variable.
Michelle A Williams +10 more
semanticscholar +1 more source
Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus [PDF]
Biochemical Journal, 1994 Reduced affinity of penicillin-binding proteins (PBPs) for binding penicillin has been proposed as a mechanism of beta-lactam antibiotic resistance in staphylococci. Penicillin binding by PBPs of three penicillin-susceptible and two penicillin-resistant strains of Staphylococcus aureus was studied in kinetic assays to determine rate constants, drug ...
H F, Chambers +2 more
openaire +2 more sources
Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands
The Cell Surface, 2021 Bacteria encase their cytoplasmic membrane with peptidoglycan (PG) to maintain the shape of the cell and protect it from bursting. The enlargement of the PG layer is facilitated by the coordinated activities of PG synthesising and -cleaving enzymes.
Jad Sassine +3 more
doaj +1 more source
Penicillin-binding proteins of bdellovibrios [PDF]
Journal of Bacteriology, 1988 We examined the predacious gram-negative bacterium Bdellovibrio bacteriovorous 109J and free-living strains 109J-A1 and 109J-KA1 derived therefrom for penicillin-binding proteins (PBPs). We compared their PBPs with those of the host bacterium, Escherichia coli, and with those of a facultatively predacious bdellovibrio, B. stolpii UKi2, grown axenically.
J T, Park, S, Mahadevan
openaire +2 more sources
BMC Chemistry, 2023 Amphotericin B (AMPH) is an anti-fungal drug and this study, for the first time as best of our knowledge, reports the repurposing of the Amphotericin B.
Neha Farid +4 more
doaj +1 more source
Penicillin-binding proteins in bacteria [PDF]
Antimicrobial Agents and Chemotherapy, 1980 The penicilllin-binding proteins (PBPs) of several gram-positive and gram-negative bacteria have been examined. The results indicate that: (i) PBPs are membrane proteins with molecular weights ranging from 40,000 to 120,000. When extracted with Triton X-100 from sonicated cells, they appear to fall into two patterns: one found in rods and the other in ...
N H, Georgopapadakou, F Y, Liu
openaire +2 more sources
Penicillins: update for clinical practice
Revista Médica de Minas Gerais, 2023 Introduction: The discovery of penicillins is one of the milestones in the history of health care. These drugs are among the most prescribed antimicrobials in the world, with applicability even today in different diseases and infectious complications ...
Rodrigo Siqueira-Batista +5 more
doaj +1 more source
Life, 2022 Shigella sonnei remains the second most common cause of shigellosis in young children and is now increasingly dominant across developing countries. The global emergence of drug resistance has become a main burden in the treatment of S.
Mohd Zulkifli Salleh +2 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2020 Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml ...
Saquib Malik +3 more
semanticscholar +1 more source