Results 191 to 200 of about 635,610 (300)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Structural and Dynamics Analyses of β-Lactam Inhibition of <i><i>Streptococcus pneumoniae</i></i> Penicillin-Binding Protein 1b (PBP1b) Guide Interrogation of Structure-Activity Relationships. [PDF]

ACS Chem Biol
Flanders PL, Gillingham JR, Contreras-Martel C, Dessen A, Carlson EE, Ambrose EA.   +5 more
europepmc   +1 more source

Live-Cell Profiling of Penicillin-Binding Protein Inhibitors in Escherichia coli MG1655. [PDF]

ACS Infect Dis, 2022
Shirley JD, Nauta KM, Carlson EE.
europepmc   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

Synthesis and Antibacterial Evaluation of an Indole Triazole Conjugate with In Silico Evidence of Allosteric Binding to Penicillin-Binding Protein 2a. [PDF]

Pharmaceutics
Sanapalli V, Sanapalli BKR, Mohammed AA.
europepmc   +1 more source

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile. [PDF]

mBio, 2023
Dingle KE, Freeman J, Didelot X, Quan TP, Eyre DW, Swann J, Spittal WD, Clark EV, Jolley KA, Walker AS, Wilcox MH, Crook DW.   +11 more
europepmc   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Novel Quinazolinones Active against Multidrug-Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin-Binding Protein 1A as a Potential Target. [PDF]

ChemMedChem
Kerda M, Nawrot D, Šlechta P, Domanský M, Askari A, Kamangar H, Janďourek O, Konečná K, Paterová P, Hlbočanová I, Macháček M, Mori M, Meneghetti F, Doležal M, Zitko J, Bouz G.   +15 more
europepmc   +1 more source

Inhibition Mechanism of Methicillin-Resistant Staphylococcus aureus by Zinc Oxide Nanorods via Suppresses Penicillin-Binding Protein 2a. [PDF]

ACS Omega, 2023
Hassan A, Al-Salmi FA, Saleh MA, Sabatier JM, Alatawi FA, Alenezi MA, Albalwe FM, Meteq R Albalawi H, Darwish DBE, Sharaf EM.   +9 more
europepmc   +1 more source

Serine Beta-Lactamases And Penicillin-Binding Proteins [PDF]

Annual Review of Microbiology, 1991
openaire   +3 more sources