Results 61 to 70 of about 460,006 (298)

Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium

Gut Pathogens, 2022
Enterococcus faecium is an emerging ESKAPE bacterium that is capable of causing severe public health complications in humans. There are currently no licensed treatments or vaccinations to combat the deadly pathogen.
Jyotirmayee Dey, Soumya Ranjan Mahapatra, T. Kiran Raj, Taranjeet Kaur, Parul Jain, Arushi Tiwari, Shubhransu Patro, Namrata Misra, Mrutyunjay Suar   +8 more
doaj   +1 more source

Penicillin-binding proteins in Proteus species [PDF]

Journal of Bacteriology, 1979
Penicillin-binding proteins in three species of Proteus, Proteus mirabilis, P. morganii, and P. rettgeri, were investigated by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis. Penicillin-binding proteins in these Proteus species were compared with those in Escherichia coli K-12.
S, Ohya, M, Yamazaki, S, Sugawara, M, Matsuhashi   +3 more
openaire   +2 more sources

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications, 2016
β-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as ‘transition state analogue’ inhibitors of nucleophilic serine enzymes, including serine-β-lactamases.
J. Brem, Ricky Cain, Samuel T. Cahill, Michael A. McDonough, I. Clifton, Juan-Carlos Jiménez-Castellanos, M. Avison, James Spencer, Colin W G Fishwick, Christopher J. Schofield   +9 more
semanticscholar   +1 more source

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae

mBio, 2016
β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients.
Yuan Li, B. Metcalf, Sopio Chochua, Zhongya Li, R. Gertz, H. Walker, P. Hawkins, T. Tran, C. Whitney, L. McGee, B. Beall   +10 more
semanticscholar   +1 more source

Clinical characteristics, specific resistance patterns, and molecular mechanisms of carbapenem-resistant Morganella morganii isolates

Frontiers in Cellular and Infection Microbiology
ObjectivesThe emergence and spread of carbapenem-resistant Morganella morganii (M. morganii) pose a serious global challenge. This study aimed to investigate the clinical characteristics, resistance patterns, and molecular mechanisms of carbapenem ...
Xiangkuo Zheng, Xiangkuo Zheng, Weiliang Zeng, Yan Liu, Luozhu Feng, Jiayin Zheng, Tieli Zhou, Changrui Qian, Cui Zhou   +8 more
doaj   +1 more source

Penicillin-Binding Proteins and β-Lactam Resistance [PDF]

FEMS Microbiology Reviews, 2008
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition
Zapun, André, Macheboeuf, Pauline, Vernet, Thierry   +2 more
openaire   +3 more sources

Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery

Computational and Structural Biotechnology Journal, 2021
The penicillin-binding proteins are the enzyme catalysts of the critical transpeptidation crosslinking polymerization reaction of bacterial peptidoglycan synthesis and the molecular targets of the penicillin antibiotics.
Siseth Martínez-Caballero, Kiran V. Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F. Fisher, Inés G. Muñoz, Mayland Chang, Shahriar Mobashery, Juan A. Hermoso   +12 more
doaj   +1 more source

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance

The FEBS Journal, 2016
Mycobacterium tuberculosis is a human respiratory pathogen that causes the deadly disease tuberculosis. The rapid global spread of antibiotic‐resistant M. tuberculosis makes tuberculosis infections difficult to treat.
E. Filippova, Karen J. Kieser, C. Luan, Z. Wawrzak, O. Kiryukhina, E. Rubin, W. Anderson   +6 more
semanticscholar   +1 more source

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

Nature Communications, 2023
The two-component regulatory system VraRS regulates transcription of penicillin-binding protein 2 in response to cell wall antimicrobials. Here, Lu et al.
Yunfu Lu, Feifei Chen, Qingmin Zhao, Qiao Cao, Rongrong Chen, Huiwen Pan, Yanhui Wang, Haixin Huang, Ruimin Huang, Qian Liu, Min Li, Taeok Bae, Haihua Liang, Lefu Lan   +13 more
doaj   +1 more source

Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2014
Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the ...
Daniil M Prigozhin, Inna V Krieger, John P Huizar, Daniela Mavrici, Geoffrey S Waldo, Li-Wei Hung, James C Sacchettini, Thomas C Terwilliger, Tom Alber   +8 more
doaj   +1 more source