Results 51 to 60 of about 460,006 (298)

Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis

Journal of the American Chemical Society, 2017
The mechanism of the β-lactam antibacterials is the functionally irreversible acylation of the enzymes that catalyze the cross-linking steps in the biosynthesis of their peptidoglycan cell wall.
Kiran V. Mahasenan, R. Molina, R. Bouley, M. Batuecas, J. Fisher, J. Hermoso, Mayland Chang, S. Mobashery   +7 more
semanticscholar   +1 more source

Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences

BMC Genomics, 2017
Genomic sequence-based deduction of antibiotic minimum inhibitory concentration (MIC) has great potential to enhance the speed and sensitivity of antimicrobial susceptibility testing.
Yuan Li, B. Metcalf, Sopio Chochua, Zhongya Li, R. Gertz, H. Walker, P. Hawkins, T. Tran, L. McGee, B. Beall   +9 more
semanticscholar   +1 more source

Penicillin-binding proteins in Borrelia burgdorferi [PDF]

Journal of Bacteriology, 1990
Penicillin-binding proteins were identified in Borrelia burgdorferi membranes. A 94-kilodalton penicillin-binding protein was the first to be labeled with tritiated penicillin and was the first band to disappear in a competition experiment. Its binding ability was destroyed when membranes were preboiled. In addition, several of these penicillin-binding
C, Urban, J J, Rahal, R J, Dattwyller, P, Gorevic, B J, Luft   +4 more
openaire   +2 more sources

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

Antimicrobial Agents and Chemotherapy, 2018
Penicillin-binding proteins (PBPs) are the high-affinity target sites of all β-lactam antibiotics in bacteria. It is well known that each β-lactam covalently binds to and thereby inactivates different PBPs with various affinities.
Dhruvitkumar S. Sutaria, Bartolomé Moyá, Kari B. Green, Tae Hwan Kim, Xun Tao, Yuanyuan Jiao, A. Louie, G. Drusano, J. Bulitta   +8 more
semanticscholar   +1 more source

Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia

Electronic Journal of Biotechnology, 2016
Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied.
Liang-Mei Li, Jun Li, Xiu-Ying Zhang
doaj   +1 more source

Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus

Journal of Biological Chemistry, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) causes serious community-acquired and nosocomial infections worldwide. MRSA strains are resistant to a variety of antibiotics, including the classic penicillin and cephalosporin classes of β-lactams ...
Andrew N. Alexander, S. Chatterjee, S. Hamilton, L. Eltis, H. Chambers, N. Strynadka   +5 more
semanticscholar   +1 more source

Genome-wide identification of genes required for alternative peptidoglycan cross-linking in Escherichia coli revealed unexpected impacts of β-lactams

Nature Communications, 2022
β-lactam-induced bacterial killing is complex and not fully resolved. Authors carry out a genome-wide analysis, through penicillin-binding protein replacement, to identify genes essential for drug efficacy.
Henri Voedts, Sean P. Kennedy, Guennadi Sezonov, Michel Arthur, Jean-Emmanuel Hugonnet   +4 more
doaj   +1 more source

Emergence of Meropenem Resistance Among Cefotaxime Non-susceptible Streptococcus pneumoniae: Evidence and Challenges

Frontiers in Microbiology, 2022
The principal causative agent of acute bacterial meningitis (ABM) in children and the elderly is Streptococcus pneumoniae, with a widespread increase in penicillin resistance.
Rosemol Varghese, Soumya Basu, Ayyanraj Neeravi, Agilakumari Pragasam, V. Aravind, Richa Gupta, Angel Miraclin, Sudha Ramaiah, Anand Anbarasu, Balaji Veeraraghavan   +9 more
doaj   +1 more source

Penicillin-binding proteins of Haemophilus ducreyi [PDF]

Antimicrobial Agents and Chemotherapy, 1989
The penicillin-binding protein (PBP) profile of Haemophilus ducreyi was determined by a whole-cell-labeling assay. Only two major PBPs, of molecular weights 90,000 (PBP 1) and 38,500 (PBP 2), were detected in six of eight strains studied. Competition binding experiments and the attendant morphological effects suggested that PBP 1 was either a ...
B C, Lee, L E, Bryan
openaire   +2 more sources

Identification of pneumococcal proteins that are functionally linked to penicillin‐binding protein 2b (PBP2b)

Molecular Microbiology, 2017
The oval shape of pneumococci results from a combination of septal and lateral peptidoglycan synthesis. The septal cross‐wall is synthesized by the divisome, while the elongasome drives cell elongation by inserting new peptidoglycan into the lateral cell
D. Straume, G. A. Stamsås, Kari Helene Berg, Z. Salehian, L. Håvarstein   +4 more
semanticscholar   +1 more source