Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus [PDF]
Antimicrobial Agents and Chemotherapy, 1985 The penicillin-binding proteins (PBPs) of two methicillin-resistant strains of Staphylococcus aureus (R2 and R1) were analyzed in cells grown in the absence and in the presence of methicillin. Under the former condition, strain R2 showed the typical PBP pattern of beta-lactam-susceptible strains, while strain R1 showed a markedly increased amount of ...
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Frontiers in Cellular and Infection Microbiology, 2018 D-alanyl-D-alanine carboxypeptidase, product of dacD gene in Francisella, belongs to penicillin binding proteins (PBPs) and is involved in remodeling of newly synthetized peptidoglycan. In E.
Petra Spidlova +8 more
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Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. [PDF]
, 2014 Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Al-Ubaidi, Muayyad +7 more
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eLife, 2019 Although the peptidoglycan cell wall is an essential structural and morphological feature of most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently dispensable under standard culture conditions. By modulating a single
Elizabeth A Mueller +4 more
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On Column Binding a Real-Time Biosensor for β-lactam Antibiotics Quantification
Molecules, 2020 This work aimed to develop accurate, quick, and practical tools for the detection of residues of penicillin G antibiotic in biological and non-biological samples.
Shahla M. Abdullah, Shwan Rachid
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Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity [PDF]
, 2008 Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected.
Bugg, Charles W. +5 more
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A Specialized Peptidoglycan Synthase Promotes
mBio, 2017 Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts.
Sónia Castanheira +7 more
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Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]
, 2015 Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut +48 more
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Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. [PDF]
, 2019 HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions.
Fernandes, Jason D +4 more
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Frontiers in Cellular and Infection Microbiology, 2014 For intracellular Chlamydiaceae, there is no need to withstand osmotic challenges, and a functional cell wall has not been detected in these pathogens so far. Nevertheless, penicillin inhibits cell division in Chlamydiaceae resulting in enlarged aberrant
Stefania eDe Benedetti +7 more
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