Results 141 to 150 of about 399,815 (205)

<i>k</i>_inact/<i>K</i>_I Value Determination for Penicillin-Binding Proteins in Live Cells. [PDF]

ACS Infect Dis
Shirley JD, Gillingham JR, Nauta KM, Diwakar S, Carlson EE.   +4 more
europepmc   +1 more source

Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci. [PDF]

Antimicrob Agents Chemother, 2020
Djorić D, Little JL, Kristich CJ.
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in Enterococcus faecalis. [PDF]

Antibiotics (Basel)
Conti P, Lazzaro LM, Longo F, Lenzo F, Giardina A, Fortuna SA, Stefani S, Campanile F.   +7 more
europepmc   +1 more source

Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073. [PDF]

Chem Sci, 2021
Sargun A, Johnstone TC, Zhi H, Raffatellu M, Nolan EM.   +4 more
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Clinical isolates of <i>Streptococcus mitis/oralis</i>-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan. [PDF]

Antimicrob Agents Chemother
Sarangi J, Ido A, Ito M, Iinuma C, Doyama Y, Jin W, Wachino J-i, Suzuki M, Iguchi M, Yagi T, Arakawa Y, Kimura K.   +11 more
europepmc   +1 more source

A Small Molecule Inhibitor of CTP Synthetase Identified by Differential Activity on a Bacillus subtilis Mutant Deficient in Class A Penicillin-Binding Proteins. [PDF]

Front Microbiol, 2020
Emami K, Wu LJ, Errington J.
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects. [PDF]

Elife, 2020
Vigouroux A, Cordier B, Aristov A, Alvarez L, Özbaykal G, Chaze T, Oldewurtel ER, Matondo M, Cava F, Bikard D, van Teeffelen S.   +10 more
europepmc   +1 more source