Results 61 to 70 of about 558,213 (199)
Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2014 Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the ...
Daniil M Prigozhin +8 more
doaj +1 more source
The SARS-coronavirus-host interactome [PDF]
, 2011 Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von +27 more
core +1 more source
Non-Beta-Lactamase-Producing Penicillin-Resistant Enterococcus faecium in a Clinical Setting
Canadian Journal of Infectious Diseases, 1990 Six clinical isolates of Enterococcus faecium highly resistant to penicillin are reported. These strains did not produce beta-lactamase and no plasmid DNA could be detected.
Daniel Eymard +6 more
doaj +1 more source
Antibiotics, 2016 Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex ...
Eric Sauvage, Mohammed Terrak
doaj +1 more source
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. [PDF]
, 2015 MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA.
Dutta, Anindya +6 more
core +1 more source
BMC Research Notes, 2018 Objective β-Lactamase-negative ampicillin-resistant Haemophilus influenzae is a common opportunistic pathogen of hospital- and community-acquired infections, harboring multiple single nucleotide polymorphisms in the ftsI gene, which codes for penicillin ...
Kazuhisa Misawa +14 more
doaj +1 more source
Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease [PDF]
, 2013 Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppressesbile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in thewild type ...
Francisco García-del Portillo +4 more
core +1 more source
Lipoproteins of Mycobacterium tuberculosis : an abundant and functionally diverse class of cell envelope components [PDF]
, 2004 Mycobacterium tuberculosis remains the predominant bacterial scourge of mankind. Understanding of its biology and pathogenicity has been greatly advanced by the determination of whole genome sequences for this organism.
Harrington, Dean, Sutcliffe, Iain
core +1 more source
Penicillin-Binding Proteins in Leptospira interrogans [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT The Leptospira interrogans ponA and pbpB genes were isolated and characterized. ponA and pbpB encode the penicillin-binding proteins (PBPs) 1 and 3, respectively.
Brenot, A +3 more
openaire +4 more sources
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. [PDF]
, 2018 BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America.
Ambati, Aditya +9 more
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