Results 91 to 100 of about 401,752 (293)
eLife, 2019 Although the peptidoglycan cell wall is an essential structural and morphological feature of most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently dispensable under standard culture conditions. By modulating a single
Elizabeth A Mueller +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The enzymology of Streptococcus pneumoniae peptidoglycan polymerisation [PDF]
Bacterial cell survival depends on intact peptidoglycan, an extensive cell wall polymer of alternating N-acetylglucosamine and N-acetylmuramic acid residues, cross-linked by short peptides.
Abrahams, Katherine A.
core
, 2016 Strains used in this study and mutations detected in penicillin binding proteins, gdpP and acrB genes.
Alexander L. Greninger (123194) +5 more
core +1 more source
Importance of the E-46-D-160 Polypeptide Segment of the Non-Penicillin-Binding Module for the Folding of the Low-Affinity, Multimodular Class B Penicillin-Binding Protein 5 of Enterococcus Hirae [PDF]
, 1995 peer reviewedCompared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin-binding module because of the presence of
Partoune, Pierre +7 more
core +1 more source
A Specialized Peptidoglycan Synthase Promotes
mBio, 2017 Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts.
Sónia Castanheira +7 more
doaj +1 more source
On Column Binding a Real-Time Biosensor for β-lactam Antibiotics Quantification
Molecules, 2020 This work aimed to develop accurate, quick, and practical tools for the detection of residues of penicillin G antibiotic in biological and non-biological samples.
Shahla M. Abdullah, Shwan Rachid
doaj +1 more source
Peptidoglycan recruitment by a penicillin binding protein
Nature CommunicationsAbstract The cell wall is essential for bacterial survival. Its core component is peptidoglycan (PG), a polymer comprised of disaccharide-peptides (stem peptides) that are cross-linked to one another via transpeptidation by penicillin-binding proteins (PBPs). While much is known about how PBPs are inactivated by β-
Yamanappa Hunashal +11 more
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Characterisation of pneumococcal peptidoglycan cross-linking enzymology [PDF]
Despite the introduction of penicillin, infections caused by Streptococcus pneumoniae are associated with significant morbidity and mortality. As a result, there is an urgent need for successful identification of new drug targets within the organism ...
Shepherd, Jennifer
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