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Penicillin-binding proteins inStreptococcus mitis
Current Microbiology, 1992The penicillin-binding protein (PBP) profiles of penicillin-susceptible and-resistant clinical isolates ofStreptococcus mitis varied even with strains with similar minimal inhibitory concentrations (MICs).S. mitis NCTC 10712 was used as a DNA recipient to investigate PBP alterations which could occur as a result of spontaneous mutation and intra- and ...
Elsa Potgieter +2 more
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Microbiologica, 1986
Penicillin-binding protein 5 of Streptococcus faecium has been solubilized and partially separated from other membrane proteins by covalent affinity chromatography. PBP 5 was successively purified to homogeneity by resolution on SDS-polyacrylamide gel, elution and renaturation of penicillin-binding activity.
A. Grossato +4 more
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Penicillin-binding protein 5 of Streptococcus faecium has been solubilized and partially separated from other membrane proteins by covalent affinity chromatography. PBP 5 was successively purified to homogeneity by resolution on SDS-polyacrylamide gel, elution and renaturation of penicillin-binding activity.
A. Grossato +4 more
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Penicillin-Binding Proteins of Gram-Negative Bacteria
Clinical Infectious Diseases, 1988beta-Lactam antibiotics exert their antibacterial effects by inactivating the high-molecular-weight penicillin-binding proteins (PBPs) that are responsible for the final stages of peptidoglycan biosynthesis. The availability of the amino acid sequences of several low-molecular-weight PBPs, high-molecular-weight PBPs, and active-site serine beta ...
B G, Spratt, K D, Cromie
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A Method to Assay Penicillin-Binding Proteins
2008Key enzymes that assemble the bacterial cell wall are also the target of the Beta-lactam class of antibiotics. The covalent binding of labeled penicillin to these proteins has been used in numerous studies in drug discovery, antibiotic mechanisms of action and resistance, and cell wall physiology.
Michael J, Pucci, Thomas J, Dougherty
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Penicillin-Binding Protein 5 of Escherichia coli
2013Refereed/Peer ...
Malika Kumarasiri +2 more
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Pathogenesis, epidemiology and control of Group A Streptococcus infection
Nature Reviews Microbiology, 2023Stephan Brouwer, Bodie Curren
exaly
Penicillin-binding proteins of Bacteroides fragilis
Journal of Antimicrobial Chemotherapy, 1984BOTTA GA +2 more
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