Results 111 to 120 of about 486,095 (301)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Penicillin-binding proteins involved in high-level piperacillin resistance in Veillonella spp. [PDF]
, 2003 Magda Theron
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Consumption of antibiotics within ambulatory care in Malta [PDF]
, 2011 Background: Antibiotic use is recognised as the most important driver for the development of antimicrobial resistance in community pathogens. Surveillance is therefore critical for improvement programmes.
Borg, Michael Angelo, Zarb, Peter
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Resistance of Escherichia coli Isolated from Water Sources on West Lombok Farms to Antibiotics
Media Kedokteran HewanAntibiotics are frequently used arbitrarily in livestock industry without regards for dosage or norms use. The administration of antibiotics to livestock can lead to a decline in their efficacy and contribute to the emergence of antibiotic resistance ...
Novarina Sulsia Ista'In Ningtyas +3 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2012 Background: A major concern about S. pneumoniae is the emergence of resistance to antibiotics, especially to penicillin. The aim of this study was to assess the role of PBPs gene in penicillin resistance of S.
Mohammad Kargar +2 more
doaj
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function [PDF]
, 2013 Lisandro H. Otero +14 more
openalex +1 more source